Photoreceptor degeneration changes magnetic resonance imaging features in a mouse model of retinitis pigmentosa.
Photoreceptor degeneration changes magnetic resonance imaging features in a mouse model of retinitis pigmentosa.
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DOI：
10.1002/mrm.22751
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发表时间：
2011-06
影响因子：
3.3
通讯作者：
Chen, Junjie
中科院分区：
文献类型：
--
作者：
Wang, Qing;Song, Sheng-Kwei;Zhang, Huiying;Berkowitz, Bruce A.;Chen, Shiming;Wickline, Samuel A.;Chen, Junjie
视网膜变性-1（rd 1）小鼠是视网膜色素变性的动物模型，视网膜色素变性是一种由感光细胞变性引起的致盲疾病。本研究旨在确定1个月和3个月大的rd 1小鼠视网膜的磁共振成像（MRI）变化。采用扩散MRI测量视网膜表观扩散系数。在全身注射钆-二乙烯三胺五乙酸之前和之后，使用钆-二乙烯三胺五乙酸增强的T1加权MRI评价血视网膜屏障渗漏。在1月龄和3月龄的rd 1小鼠中，rd 1视网膜的光感受器变性是明显的，表现为视网膜厚度的减少和水扩散各向异性的丧失。此外，与年龄匹配的野生型小鼠相比，在3月龄的rd 1小鼠中观察到平均视网膜表观扩散系数和钆-二乙烯三胺五乙酸增强的T1加权MRI信号的统计学显著增加。总之，这些数据表明，MRI参数的变化可以签名常见的光感受器退化的眼睛，特别是血视网膜屏障渗漏诱导的视网膜水肿的病理变化。
Retinal degeneration-1 (rd1) mice are animal models of retinitis pigmentosa, a blinding disease caused by photoreceptor cell degeneration. This study aims to determine magnetic resonance imaging (MRI) changes in retinas of 1- and 3-month-old rd1 mice. Apparent diffusion coefficient in retina was measured using diffusion MRI. The blood-retinal barrier leakage was evaluated using gadolinium-diethylenetriaminepentaacetic acid-enhanced T1-weighted MRI before and after systemic gadolinium-diethylenetriaminepentaacetic acid injection. Photoreceptor degeneration in rd1 retina was apparent by decreased retinal thickness and loss of water diffusion anisotropy in both 1- and 3-month-old rd1 mice. Furthermore, statistically significant increase of mean retinal apparent diffusion coefficient and gadolinium-diethylenetriaminepentaacetic acid-enhanced T1-weighted MRI signals were observed in 3-month-old rd1 mice comparing with age-matched wild-type mice. Together, these data suggest that MRI parameter changes can signature common pathological changes in photoreceptor-degenerated eyes, particularly blood-retinal barrier leakage-induced retinal edema.
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影响因子：
1.8
作者：
Kim, Ki Hean;Puoris'haag, Mehron;de Boer, Johannes F.
通讯作者：
de Boer, Johannes F.
影响因子：
3.4
作者：
Neuhardt, T;May, CA;Lütjen-Drecoll, E
通讯作者：
Lütjen-Drecoll, E
影响因子：
4.4
作者：
Berkowitz, BA;Roberts, R;Thomas, KA
通讯作者：
Thomas, KA
影响因子：
4.1
作者：
Kuroiwa, T;Nagaoka, T;Hirakawa, K
通讯作者：
Hirakawa, K
影响因子：
3.9
作者：
Hajali, M.;Fishman, G. A.
通讯作者：
Fishman, G. A.