Retinal nerve fiber layer thickness in subgroups of multiple sclerosis, measured by optical coherence tomography and scanning laser polarimetry.
Retinal nerve fiber layer thickness in subgroups of multiple sclerosis, measured by optical coherence tomography and scanning laser polarimetry.
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DOI：
10.1007/s00415-010-5589-1
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发表时间：
2010-10
影响因子：
6
通讯作者：
Hintzen RQ
中科院分区：
文献类型：
--
作者：
Siepman TA;Bettink-Remeijer MW;Hintzen RQ
光学相干断层扫描(OCT)和扫描激光偏振仪(GDX ECC)是评估视网膜神经纤维层(RNFL)厚度的无创性方法，可能是监测多发性硬化(MS)轴突丢失的可靠工具。本研究的目的是(1)比较OCT和GDX ECC；(2)评估和比较MS各亚型的RNFL厚度。对65例MS患者(26例复发缓解(RRMS)，10例继发进展型(SPMS)，29例原发进展型(PPMS))进行眼科检查和OCT和GDX的RNFL评估。28例患者(43%)有视神经炎病史(ON)。对年龄和病程进行了调整。RNFL厚度较术前降低(P<0.01)。PPMS和复发患者之间没有发现差异。OCT和GDX ECC测量结果呈中度相关(Rho=0.73，p<0.01)。视野-平均偏差(MD)值与OCT平均值(r=0.44，P<0.01)和GDX ECC TSNIT平均值(r=0.41，P<0.01)相关。在无病史的患者中，EDSS与MD(r=0.36，P<0.01)、视野模式标准差(r=0.30，P<0.05)、OCT平均值(r=0.31~0.30，P<0.05)和黄斑体积(r=−=0.37，P<0.01)相关。对于MSIS-29身体冲击评分，与MD(r=0.48，p<0.01)和−(r=0.48，p<0.01)显著相关。结论：PPMS亚组与复发性MS亚组之间无差异。RNFL厚度较术前明显减少。虽然OCT和GDX ECC检查结果与无病史的患者的视功能指标呈中度相关，但EDSS与视觉和OCT检查结果显著相关，而与GDX ECC检查结果无关。
Optical coherence tomography (OCT) and scanning laser polarimetry (GDx ECC) are non-invasive methods used to assess retinal nerve fiber layer (RNFL) thickness, which may be a reliable tool used to monitor axonal loss in multiple sclerosis (MS). The objectives of this study are (1) to compare OCT with the GDx ECC; (2) to assess and compare the RNFL thickness in subgroups of MS. Ophthalmologic examination and RNFL assessment by OCT and GDx were performed in 65 MS patients (26 relapsing-remitting (RRMS), ten secondary-progressive (SPMS), 29 primary-progressive (PPMS)). Twenty-eight patients (43%) had a history of optic neuritis (ON). Adjustments were made for age and disease duration. RNFL thickness was reduced in eyes with previous ON (p < 0.01). No differences were found between PPMS and relapse-onset MS. OCT and GDx ECC measurements were moderately correlated (rho = 0.73, p < 0.01). Visual field-mean deviation (MD) values correlated with OCT means (r = 0.44, p < 0.01) and GDx ECC TSNIT average (r = 0.41, p < 0.01). In patients without previous ON, EDSS correlated with MD (r = −0.36, p < 0.01), visual field-pattern standard deviation (PSD) (r = 0.30, p < 0.05), OCT means (r = −0.31–0.30, p < 0.05) and macular volume (r = −0.37, p < 0.01). For MSIS-29 physical impact score, significant correlations were found with MD (r = −0.48, p < 0.01) and PSD (r = 0.48, p < 0.01). Conclusions: No differences between PPMS and relapse-onset MS subgroups were found. RNFL thickness was reduced in eyes with previous ON. Although OCT and GDx ECC findings were moderately correlated and showed significant correlations with measures of visual function in patients without previous ON, EDSS correlated significantly with visual and OCT measures, but not with GDx ECC.
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影响因子：
3.9
作者：
Blumenthal, E. Z.;Parikh, R. S.;Thomas, R.
通讯作者：
Thomas, R.
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作者：
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