Cellular and molecular effects of hyperglycemia on ion channels in vascular smooth muscle.
Cellular and molecular effects of hyperglycemia on ion channels in vascular smooth muscle.
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DOI：
10.1007/s00018-020-03582-z
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Navedo MF
中科院分区：
文献类型：
--
作者：
Nieves-Cintrón M;Flores-Tamez VA;Le T;Baudel MM;Navedo MF
糖尿病影响着全世界数百万人。这种毁灭性的疾病大大增加了患心血管疾病的风险。糖尿病的一个标志性代谢异常是高血糖症，它有助于心血管并发症的发病机制。这些心血管并发症至少部分与高血糖诱导的构成血管的细胞中的分子和细胞变化有关。尽管高血糖期间介导内皮功能障碍的机制已被广泛研究，但对高血糖如何影响血管平滑肌功能知之甚少。血管平滑肌的功能受到许多离子通道的精细调节，包括钾（K+）通道超家族的几个成员和电压门控L型Ca 2+通道。高血糖对血管平滑肌离子通道功能的调节是糖尿病血管功能障碍的一个关键因素。本文就糖尿病高血糖如何调节血管平滑肌中这些离子通道的活性作一综述。我们研究了肌张力和血管反应性的潜在机制、一般性质和生理相关性。
Diabetes affects millions of people worldwide. This devastating disease dramatically increases the risk of developing cardiovascular disorders. A hallmark metabolic abnormality in diabetes is hyperglycemia, which contributes to the pathogenesis of cardiovascular complications. These cardiovascular complications are, at least in part, related to hyperglycemia-induced molecular and cellular changes in the cells making up blood vessels. Whereas the mechanisms mediating endothelial dysfunction during hyperglycemia have been extensively examined, much less is known about how hyperglycemia impacts vascular smooth muscle function. Vascular smooth muscle function is exquisitely regulated by many ion channels, including several members of the potassium (K+) channel superfamily and voltage-gated L-type Ca2+ channels. Modulation of vascular smooth muscle ion channels function by hyperglycemia is emerging as a key contributor to vascular dysfunction in diabetes. In this review, we summarize the current understanding of how diabetic hyperglycemia modulates the activity of these ion channels in vascular smooth muscle. We examine underlying mechanisms, general properties, and physiological relevance in the context of myogenic tone and vascular reactivity.
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DOI：
10.1111/micc.12046
发表时间：
2013-05
期刊：
Microcirculation (New York, N.Y. : 1994)
影响因子：
--
作者：
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Navedo MF
影响因子：
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2005-08-01
影响因子：
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10.1152/ajpheart.00699.2009
发表时间：
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影响因子：
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