Increased rate of formation of small-sized platelet aggregates in patients with acute coronary syndromes.
Increased rate of formation of small-sized platelet aggregates in patients with acute coronary syndromes.
复制标题
急性冠状动脉综合征患者小尺寸血小板聚集体形成率增加。
DOI：
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
H. Yasue
中科院分区：
文献类型：
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作者：
S. Miyamoto;H. Ogawa;H. Soejima;K. Takazoe;I. Kajiwara;T. Sakamoto;M. Yoshimura;K. Kugiyama;H. Yasue
冠状动脉血栓形成与急性冠状动脉综合征的发病有关，血小板活化在冠状动脉血栓形成中起着关键作用。本文介绍了一种新型的激光散射血小板聚集仪。采用激光散射法对23例急性冠脉综合征患者入院时及治疗后血小板聚集性，尤其是小血小板聚集性进行了研究。同时测定了14例稳定劳力型心绞痛患者和14例正常对照者的血小板聚集性。入院时，急性冠状动脉综合征组的中小血小板聚集体数量显著高于稳定劳力型心绞痛组或对照组。然而，在急性冠脉综合征组中，入院时大尺寸血小板聚集体的数量没有增加。此外，在急性冠脉综合征组中，治疗后中小型血小板聚集体的数量显著减少。小尺寸血小板聚集体数量的增加可能敏感地反映了急性冠状动脉综合征患者血栓形成的发作。
Coronary thrombosis has been implicated in the pathogenesis of acute coronary syndromes, and platelet activation plays a pivotal role in the pathogenesis of coronary thrombus. A new platelet aggregometer using a laserlight scattering beam was trialled for assessment of platelet aggregation. Platelet aggregability, especially small-sized platelet aggregates, was investigated on admission using the laser-light scattering method and again after treatment in 23 patients with acute coronary syndromes. The platelet aggregability in 14 patients with stable exertional angina and in 14 control subjects was also examined. On admission, the number of small- and medium-sized platelet aggregates in the acute coronary syndromes group was significantly greater than in the stable exertional angina group or control group. However, the number of large-sized platelet aggregates on admission was not increased in the acute coronary syndromes group. Furthermore, the number of small- and medium-sized platelet aggregates decreased significantly after treatment in the acute coronary syndromes group. The increased number of small-sized platelet aggregates may sensitively reflect attacks of thrombosis in patients suffering acute coronary syndromes.
影响因子：
37.8
作者：
Goto, S;Sakai, H;Ruggeri, ZM
通讯作者：
Ruggeri, ZM