Epigenetic Implications of Neighborhood Disorder and Psychological Distress among Pregnant Black Women.
Epigenetic Implications of Neighborhood Disorder and Psychological Distress among Pregnant Black Women.
复制标题
DOI：
10.1177/01939459231184713
复制
发表时间：
2023-09
影响因子：
1.8
通讯作者：
Giurgescu, Carmen
中科院分区：
文献类型：
--
作者：
Nowak, Alexandra L.;Anderson, Cindy M.;Zhao, Yihong;Ford, Jodi L.;Mackos, Amy R.;Ohm, Joyce;Tan, Alai;Saadat, Nadia;Misra, Dawn P.;Giurgescu, Carmen
在美国，黑人妇女经历早产（<37周妊娠）的比率是非西班牙裔白色妇女的1.5倍以上。健康的社会决定因素，包括邻里环境，已被公认为有助于早产的风险。由于历史上的种族隔离，与白色妇女相比，黑人妇女更有可能生活在邻里关系混乱程度较高的社区。感知邻里障碍似乎是一个危险因素，母亲的心理困扰，在黑人妇女和心理困扰介导邻里障碍和早产风险之间的关联。然而，支撑这些关联的生物学途径尚不清楚。我们研究了44名黑人孕妇的邻里关系障碍、心理困扰、6个应激相关的糖皮质激素候选基因（AVP、CRH、CRHBP、FKBP 5、HSD 11B 2、NR 3C 1）的DNA甲基化与出生时胎龄之间的关系。对18-45岁、妊娠8-18周的妇女进行抽血，并完成问卷调查，测量感知的邻里关系障碍、邻里犯罪和心理困扰。3个CpG位点与邻近区疾病相关，分别为cg 03405789（CRH）、cg 14939152、cg 15910486（NR 3C 1）。一个CpG位点cg 03098337（FKBP 5）与心理困扰相关。三个已确定的CpG位点位于基因CpG岛或海岸区域内，已知DNA甲基化会影响基因转录。这些发现需要进一步研究，以澄清中间生物学途径和潜在的生物标志物，以识别有PTB风险的女性。在怀孕早期识别PTB风险将允许干预措施，以防止PTB。美国黑人妇女的早产率明显高于白色妇女。包括邻里环境在内的社会决定因素被认为是导致早产风险的因素。与白色女性相比，黑人女性更有可能生活在障碍水平较高的社区，心理困扰介导了社区障碍与早产风险之间的关联。然而，支撑这些关联的生物学途径尚不清楚。我们研究了44名黑人孕妇中6个与压力相关的候选基因的DNA甲基化、邻里关系障碍、心理困扰和出生时胎龄。三个基因中的四个CpG位点与邻里关系障碍或心理困扰有关。需要进一步的研究来阐明生物学途径，并确定有PTB风险的妇女的生物标志物。在怀孕早期识别PTB风险将允许干预措施，以防止PTB。
In the United States, Black women experience preterm birth (<37 weeks gestation) at more than 1.5 times the rate of non-Hispanic White women. Social determinants of health including the neighborhood environment have been recognized as contributing to the risk of preterm birth. Due to historical segregation, Black women are more likely to live in neighborhoods with higher levels of neighborhood disorder compared with White women. Perceived neighborhood disorder appears to be a risk factor for maternal psychological distress in Black women and psychological distress has mediated the association between neighborhood disorder and the risk for preterm birth. However, the biological pathways underpinning these associations are not clear. We examined the associations among neighborhood disorder, psychological distress, DNA methylation of six stress-related, glucocorticoid candidate genes (AVP, CRH, CRHBP, FKBP5, HSD11B2, NR3C1) and gestational age at birth among 44 Black pregnant women. Women who were 18–45 years old and 8–18 weeks gestation had blood drawn and completed questionnaires measuring perceived neighborhood disorder, neighborhood crime, and psychological distress. Three CpG sites were associated with neighborhood disorder—cg03405789 (CRH), and cg14939152, cg15910486 (NR3C1). One CpG site, cg03098337 (FKBP5) was associated with psychological distress. Three of the identified CpG sites were located within gene CpG Islands or shores—areas at which DNA methylation is known to affect gene transcription. These findings warrant further research to clarify intermediate biological pathways and potential biomarkers to identify women at risk for PTB. Identification of PTB risk early in pregnancy would allow for interventions to prevent PTB. U.S. Black women experience preterm birth at significantly higher rates than White women. Social determinants including the neighborhood environment are recognized as contributing to the risk of preterm birth. Black women are more likely to live in neighborhoods with higher levels of disorder compared with White women, and psychological distress has mediated the association between neighborhood disorder and the risk for preterm birth. However, the biological pathways underpinning these associations are unknown. We examined DNA methylation of six stress-related candidate genes, neighborhood disorder, psychological distress, and gestational age at birth among 44 Black pregnant women. Four CpG sites in three genes were associated with neighborhood disorder or psychological distress. Further research is needed to clarify biological pathways and identify biomarkers in women at risk for PTB. Identification of PTB risk early in pregnancy would allow for interventions to prevent PTB.
登录
查看更多内容
DOI：
10.1111/j.1552-6909.2012.01409.x
发表时间：
2012-11-01
影响因子：
1.8
作者：
Giurgescu, Carmen;Zenk, Shannon N.;Block, Richard
通讯作者：
Block, Richard
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
1.2
作者：
Hossack, Michael R.;Reid, Matthew W.;Willis, Adam M.
通讯作者：
Willis, Adam M.
影响因子：
5.8
作者：
Kelly, Scott A.;Panhuis, Tami M.;Stoehr, Andrew M.
通讯作者：
Stoehr, Andrew M.
影响因子：
--
作者：
Gelaye, B;Kirschbaum, C;Williams, M A
通讯作者：
Williams, M A