Spatial distribution and populations at risk of A. lumbricoides and T. trichiura co-infections and infection intensity classes: an ecological study.
Spatial distribution and populations at risk of A. lumbricoides and T. trichiura co-infections and infection intensity classes: an ecological study.
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DOI：
10.1186/s13071-018-3107-y
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发表时间：
2018-10-03
影响因子：
3.2
通讯作者：
Soares Magalhães RJ
中科院分区：
文献类型：
--
作者：
Owada K;Lau CL;Leonardo L;Clements ACA;Yakob L;Nielsen M;Carabin H;Soares Magalhães RJ
土壤传播的蠕虫（STH）感染在菲律宾非常普遍。绘制STH合并感染的流行程度和高强度，有助于指导有针对性的干预计划，以降低发病率，特别是在脆弱的学龄儿童中。在这项研究中，我们旨在预测菲律宾蛔虫和毛滴虫共感染流行率的空间分布和感染强度等级，以确定最需要干预的人群。在2005年至2007年的全国寄生虫学调查中，来自29,919个人的STH感染数据被纳入分析。建立了包括年龄、性别、环境变量和地统计随机效应在内的贝叶斯多项式地统计模型，对虫毛拟虫和毛毛拟虫共感染的流行程度和感染强度进行了地理预测。通过将预测流行率图与人口密度图相结合，预测2017年每种感染强度等级的合并感染人数。我们的模型显示，与其他年龄组相比，学龄儿童（5-19岁）最有可能同时感染类蚓蛔虫和毛虫蛔虫，感染强度为中/高。我们确定了与sst相关的发病率可能性最高的目标省份：吕宋岛（布拉干、本盖特、卡菲特、索索贡、马尼拉都会区、邦板牙和黎萨尔），米沙鄢群岛（宿务、伊洛伊洛、莱特岛和西内格罗），以及棉兰老岛（北阿古桑、南达沃、东达沃、南拉诺、马金达瑙岛、东米萨米斯、苏禄和南三宝颜岛）。吕宋岛估计有最多的学龄儿童同时感染类蚓绦虫和毛虫绦虫（估计总数为89400人），其次是米沙鄢群岛（38300人）和棉兰老岛（20200人）。我们的研究提供了流行病学证据，以突出菲律宾控制合并感染和高强度感染的国家优先领域。我们的地图可以帮助更有地理针对性的干预措施，以降低菲律宾sth相关发病率的风险。本文的在线版本（10.1186/s13071-018-3107-y）包含补充材料，授权用户可使用。
Soil-transmitted helminth (STH) infections are highly prevalent in the Philippines. Mapping the prevalence and high-intensity of STH co-infections can help guide targeted intervention programmes to reduce morbidity, especially among vulnerable school-aged children. In this study, we aimed to predict the spatial distribution of the prevalence of Ascaris lumbricoides and Trichuris trichiura co-infection and infection intensity classes in the Philippines to identify populations most in need of interventions. Data on STH infections from 29,919 individuals during the nationwide parasitological survey in 2005 to 2007 were included in the analysis. To geographically predict the prevalence of A. lumbricoides and T. trichiura co-infections and infection intensity classes, Bayesian multinomial geostatistical models were built including age, sex, environmental variables and a geostatistical random effect. The number of individuals co-infected and belonging to each of the infection intensity classes in 2017 was forecast by combining our predictive prevalence maps with population density maps. Our models showed that school-aged children (5–19 years) are most at risk of A. lumbricoides and T. trichiura co-infections and of moderate/high infection intensity compared to other age groups. We identified target provinces where the likelihood of STH-associated morbidity was highest: Luzon (Bulacan, Benguet, Cavite, Sorsogon, Metropolitan Manila, Pampanga and Rizal), the Visayas (Cebu, Iloilo, Leyte and Negros Occidental), and in Mindanao (Agusan Del Norte, Davao Del Sur, Davao Oriental, Lanao Del Sur, Maguindanao, Misamis Oriental, Sulu and Zamboanga Del Sur). Luzon had the highest estimated number of school-aged children with A. lumbricoides and T. trichiura co-infections (estimated total 89,400), followed by the Visayas (38,300) and Mindanao (20,200). Our study provided epidemiological evidence to highlight national priority areas for controlling co-infections and high intensity infections in the Philippines. Our maps could assist more geographically targeted interventions to reduce the risk of STH-associated morbidity in the Philippines. The online version of this article (10.1186/s13071-018-3107-y) contains supplementary material, which is available to authorized users.
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影响因子：
2.4
作者：
Clements, A. C. A.;Moyeed, R.;Brooker, S.
通讯作者：
Brooker, S.
影响因子：
2.7
作者：
Bhagwan, J. N.;Still, D.;Foxon, K.
通讯作者：
Foxon, K.
全球流行病学，生态学和控制土壤传播的蠕虫感染。
影响因子：
--
作者：
Brooker, S.;Clements, A. C. A.;Bundy, D. A. P.
通讯作者：
Bundy, D. A. P.
影响因子：
9.6
作者：
Brooker S;Hay SI;Bundy DA
通讯作者：
Bundy DA
影响因子：
2
作者：
Belizario, Vicente, Jr.;Chua, Paul Lester;Erfe, Jeffrey Mark
通讯作者：
Erfe, Jeffrey Mark