Massive genomic variation and strong selection in Arabidopsis thaliana lines from Sweden.
Massive genomic variation and strong selection in Arabidopsis thaliana lines from Sweden.
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DOI：
10.1038/ng.2678
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发表时间：
2013-08
期刊：
影响因子：
30.8
通讯作者：
Nordborg, Magnus
中科院分区：
文献类型：
--
作者：
Long, Quan;Rabanal, Fernando A.;Meng, Dazhe;Huber, Christian D.;Farlow, Ashley;Platzer, Alexander;Zhang, Qingrun;Vilhjalmsson, Bjarni J.;Korte, Arthur;Nizhynska, Viktoria;Voronin, Viktor;Korte, Pamela;Sedman, Laura;Mandakova, Terezie;Lysak, Martin A.;Seren, Uemit;Hellmann, Ines;Nordborg, Magnus
尽管测序取得了进展，但获得群体遗传变异的全面视图的目标仍然远远没有达到。我们对180条A.我们从瑞典引进了一种拟南芥，以获得尽可能完整的单一地区变异的图片。尽管基因组独特部分的简单多态性很容易识别，但其他多态性却不能。通过流式细胞术鉴定的基因组大小的巨大变化似乎主要是由于45 S rDNA拷贝数的变化，来自瑞典北方的品系具有特别大的拷贝数。强选择是明显的，在长距离连锁不平衡（LD）的形式，以及在LD附近的补偿突变。在来自瑞典北方的品系中发现了许多选择性扫描的足迹，并且显示大规模的全球扫描涉及700 kb的转座。
Despite advances in sequencing, the goal of obtaining a comprehensive view of genetic variation in populations is still far from reached. We sequenced 180 lines of A. thaliana from Sweden to obtain as complete a picture as possible of variation in a single region. Whereas simple polymorphisms in the unique portion of the genome are readily identified, other polymorphisms are not. The massive variation in genome size identified by flow cytometry seems largely to be due to 45S rDNA copy number variation, with lines from northern Sweden having particularly large numbers of copies. Strong selection is evident in the form of long-range linkage disequilibrium (LD), as well as in LD between nearby compensatory mutations. Many footprints of selective sweeps were found in lines from northern Sweden, and a massive global sweep was shown to have involved a 700-kb transposition.
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影响因子：
64.8
作者：
Gan X;Stegle O;Behr J;Steffen JG;Drewe P;Hildebrand KL;Lyngsoe R;Schultheiss SJ;Osborne EJ;Sreedharan VT;Kahles A;Bohnert R;Jean G;Derwent P;Kersey P;Belfield EJ;Harberd NP;Kemen E;Toomajian C;Kover PX;Clark RM;Rätsch G;Mott R
通讯作者：
Mott R
影响因子：
56.9
作者：
BROWN, DD;DAWID, IB
通讯作者：
DAWID, IB
影响因子：
7
作者：
Chen, Hua;Patterson, Nick;Reich, David
通讯作者：
Reich, David
影响因子：
30.8
作者：
Nordborg, M;Borevitz, JO;Weigel, D
通讯作者：
Weigel, D
影响因子：
5.3
作者：
Davison, Jerry;Tyagi, Anand;Comai, Luca
通讯作者：
Comai, Luca