Estimating sensitivity of laboratory testing for influenza in Canada through modelling.
Estimating sensitivity of laboratory testing for influenza in Canada through modelling.
复制标题
DOI：
10.1371/journal.pone.0006681
复制
发表时间：
2009-08-18
期刊：
影响因子：
3.7
通讯作者：
Tam TW
中科院分区：
文献类型：
--
作者：
Schanzer DL;Garner MJ;Hatchette TF;Langley JM;Aziz S;Tam TW
公共卫生监测系统使用每周对流感呈阳性的实验室检测的比例来确定流感活动的时期。我们的目标是根据全国呼吸道病毒监测系统的结果来评估加拿大流感检测的敏感性。根据实验室确认的流感、呼吸道合胞病毒(RSV)、腺病毒和副流感病毒的阳性检测结果，采用泊松回归方法对1999年至2006年的每周流感阴性检测次数、季节性和趋势进行建模。敏感度是通过流感阳性测试的数量除以流感阳性测试的数量加上模型估计的假阴性测试数量来计算的。流感检测的敏感性估计为33%(95%可信区间32-34%)，根据季节和地区的不同从30%-40%不等。向这一国家实验室监测系统报告的流感检测的估计敏感性大大低于报告的大多数实验室检测的检测特征。许多因素可能会解释这种差异，包括样品质量和样品采购问题以及测试特点。诊断的改进将使人们能够更好地估计流感的负担。
The weekly proportion of laboratory tests that are positive for influenza is used in public health surveillance systems to identify periods of influenza activity. We aimed to estimate the sensitivity of influenza testing in Canada based on results of a national respiratory virus surveillance system. The weekly number of influenza-negative tests from 1999 to 2006 was modelled as a function of laboratory-confirmed positive tests for influenza, respiratory syncytial virus (RSV), adenovirus and parainfluenza viruses, seasonality, and trend using Poisson regression. Sensitivity was calculated as the number of influenza positive tests divided by the number of influenza positive tests plus the model-estimated number of false negative tests. The sensitivity of influenza testing was estimated to be 33% (95%CI 32–34%), varying from 30–40% depending on the season and region. The estimated sensitivity of influenza tests reported to this national laboratory surveillance system is considerably less than reported test characteristics for most laboratory tests. A number of factors may explain this difference, including sample quality and specimen procurement issues as well as test characteristics. Improved diagnosis would permit better estimation of the burden of influenza.
登录
查看更多内容
DOI：
10.1016/0732-8893(86)90033-7
发表时间：
1986-11-01
影响因子：
2.9
作者：
ARENS, MQ;SWIERKOSZ, EM;RIVETNA, KA
通讯作者：
RIVETNA, KA
影响因子：
11.8
作者：
Louie, JK;Hacker, JK;Drew, WL
通讯作者：
Drew, WL
影响因子：
9.4
作者：
Erdman, DD;Weinberg, GA;Anderson, LJ
通讯作者：
Anderson, LJ
影响因子：
28.2
作者：
Cooper, D. L.;Smith, G. E.;George, R. C.
通讯作者：
George, R. C.
影响因子：
9.4
作者：
Ruest, A;Michaud, S;Frost, EH
通讯作者：
Frost, EH