Stimulation of calcium uptake by 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) in rabbit platelets: possible involvement of the lipoxygenase pathway.
Stimulation of calcium uptake by 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) in rabbit platelets: possible involvement of the lipoxygenase pathway.
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兔血小板中 1-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱（血小板激活因子）对钙吸收的刺激：可能涉及脂氧合酶途径。
DOI：
10.1016/0003-9861(83)90568-4
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发表时间：
1983
影响因子：
3.9
通讯作者：
Snyder,F
中科院分区：
文献类型：
--
作者：
Lee,TC;Malone,B;Snyder,F
1-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱（血小板活化因子）诱导兔血小板中Ca 2+摄取增加。该过程取决于细胞外Ca 2+浓度，最大刺激发生在1-3 mm处;在这些条件下的摄取被钙进入阻滞剂维拉帕米阻断。生物活性磷脂的钙摄取增加是独立的ADP诱导的血小板反应和通过环氧合酶途径形成的花生四烯酸代谢产物。然而，米帕林，对溴苯甲酰甲基溴，二十碳四炔酸，去甲二氢愈创木酸显着或完全抑制1-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱的钙摄取的刺激。当花生四烯酸被给予足够的时间被血小板代谢为其他产物时，也发生了对Ca 2+摄取的刺激。花生四烯酸和血小板活化因子没有产生相加或协同作用。我们的数据表明，花生四烯酸通过脂氧合酶途径产生的代谢产物可能是血小板活化因子诱导兔血小板钙摄取增加的介体。
1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) induces an increase of Ca2+uptake in rabbit platelets. This process depends upon the extracellular concentration of Ca2+with the maximum stimulation occurring at 1–3 mm; uptake under these conditions is blocked by verapamil, a calcium-entry blocker. Increase of calcium uptake by the bioactive phospholipid was independent of ADP-induced platelet responses and of metabolites of arachidonic acid metabolism formed through the cyclooxygenase pathway. However, mepacrine,p-bromophenacyl bromide, eicosatetraynoic acid, and nordihydroguaiaretic acid significantly or totally inhibited the stimulation of Ca2+uptake by 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine. When arachidonic acid was given sufficient time to be metabolized to other products by the platelets, stimulation of Ca2+uptake also occurred. Arachidonic acid and platelet-activating factor did not produce an additive or synergistic effect. Our data suggest that a metabolite(s) generated from arachidonic acid through the lipoxygenase pathway may be the mediator(s) responsible for the action of platelet-activating factor in the induction of increased Ca2+uptake in rabbit platelets.
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第23章.钙拮抗剂
影响因子：
--
作者：
R. Rahwan;D. Witiak;W. Muir
通讯作者：
W. Muir
磷脂酶 A2 活性位点的组氨酸。
影响因子：
2.9
作者：
J. Volwerk;W. A. Pieterson;G. H. D. Haas
通讯作者：
G. H. D. Haas
花生四烯酸在兔血小板中聚集过程中的分布和代谢及其药物修饰
影响因子：
7.3
作者：
G. J. Blackwell;W. G. Duncombe;Roderick J. Flower;M. Parsons;J. R. Vane
通讯作者：
J. R. Vane
前列腺素合成在嗜碱性粒细胞衍生血小板激活因子诱导的兔血小板激活中的作用。
影响因子：
4.4
作者：
J. O. Shaw;M. Printz;K. Hirabayashi;P. Henson
通讯作者：
P. Henson
单羟基二十碳四烯酸和二羟基二十碳四烯酸改变兔中性粒细胞的钙稳态。
DOI：
10.1172/jci110191
发表时间：
1981
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Naccache,PH;Sha'afi,RI;Borgeat,P;Goetzl,EJ
通讯作者：
Goetzl,EJ