Regulation of the human catalytic subunit of telomerase (hTERT).
Regulation of the human catalytic subunit of telomerase (hTERT).
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DOI：
10.1016/j.gene.2012.01.095
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发表时间：
2012-05-01
期刊：
影响因子：
3.5
通讯作者：
Tollefsbol TO
中科院分区：
文献类型：
--
作者：
Daniel M;Peek GW;Tollefsbol TO
在过去的十年里，人们对端粒酶的调节非常感兴趣，端粒酶负责维持染色体末端的完整性，以及它在细胞永生化、肿瘤发生和癌症进展中的关键作用。端粒酶活性以端粒酶逆转录酶(TERT)基因的表达为特征，提示TERT是端粒酶活性的主要限制因子。最近的发现导致了有助于调节人类端粒酶逆转录酶(HTERT)的各种相互作用的鉴定，包括许多转录因子；进一步支持了转录在端粒酶的表达和抑制中发挥的关键作用。一些研究表明，hTERT核心启动子区域的表观遗传调节可能提供了额外的调节水平。虽然这些研究提供了关于hTERT调控的重要信息，但对于核心启动子区甲基化的作用以及随后各种激活剂和抑制剂的结合尚不明确。因此，我们发现有必要巩固和总结这些最新发展，并澄清这些差异。在这篇综述中，我们主要关注hTERT通过转录调控、各种激活物和抑制物的存在或不存在，以及DNA甲基化和组蛋白修饰的表观遗传途径的共同调节。
Over the past decade, there has been much interest in the regulation of telomerase, the enzyme responsible for maintaining the integrity of chromosomal ends, and its crucial role in cellular immortalization, tumorigenesis, and the progression of cancer. Telomerase activity is characterized by the expression of the telomerase reverse transcriptase (TERT) gene, suggesting that TERT serves as the major limiting agent for telomerase activity. Recent discoveries have led to characterization of various interactants that aid in the regulation of human TERT (hTERT), including numerous transcription factors; further supporting the pivotal role that transcription plays in both the expression and repression of telomerase. Several studies have suggested that epigenetic modulation of the hTERT core promoter region may provide an additional level of regulation. Although these studies have provided essential information on the regulation of hTERT, there has been ambiguity of the role of methylation within the core promoter region and the subsequent binding of various activating and repressive agents. As a result, we found it necessary to consolidate and summarize these recent developments and elucidate these discrepancies. In this review, we focus on the co-regulation of hTERT via transcriptional regulation, the presence or absence of various activators and repressors, as well as the epigenetic pathways of DNA methylation and histone modifications.
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影响因子：
6.4
作者：
Bai, Dong;Ueno, Lynn;Vogt, Peter K.
通讯作者：
Vogt, Peter K.
影响因子：
4.6
作者：
Chou, Chao-Kai;Lee, Dung-Fang;Sun, Hui-Lung;Li, Long-Yuan;Lin, Chun-Yi;Huang, Wei-Chien;Hsu, Jung-Mao;Kuo, Hsu-Ping;Yamaguchi, Hirohito;Wang, Ying-Nai;Liu, Mo;Wu, Hsin-Yi;Liao, Pao-Chi;Yen, Chia-Jui;Hung, Mien-Chie
通讯作者：
Hung, Mien-Chie
DOI：
10.1006/bbrc.1999.1446
发表时间：
1999-11-11
影响因子：
3.1
作者：
Asker, C;Wiman, KG;Selivanova, G
通讯作者：
Selivanova, G
影响因子：
5.3
作者：
Chen, Yuan;Knoesel, Thomas;Petersen, Iver
通讯作者：
Petersen, Iver
影响因子：
56.9
作者：
CHONG, L;VANSTEENSEL, B;DELANGE, T
通讯作者：
DELANGE, T