MARS: a mouse atlas registration system based on a planar x-ray projector and an optical camera.
MARS: a mouse atlas registration system based on a planar x-ray projector and an optical camera.
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DOI:
10.1088/0031-9155/57/19/6063
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发表时间:
2012-10-07
影响因子:
3.5
通讯作者:
Chatziioannou AF
中科院分区:
文献类型:
--
作者:
Wang H;Stout DB;Taschereau R;Gu Z;Vu NT;Prout DL;Chatziioannou AF
This paper introduces a mouse atlas registration system (MARS), composed of a stationary top-view x-ray projector and a side-view optical camera, coupled to a mouse atlas registration algorithm. This system is using the x-ray and optical images to guide a fully automatic co-registration of a mouse atlas with each subject, in order to provide anatomical reference for small animal molecular imaging systems such as Positron Emission Tomography (PET). To facilitate the registration, a statistical atlas that accounts for inter-subject anatomical variations was constructed based on 83 organ-labeled mouse micro-CT images. The statistical shape model and conditional Gaussian model techniques were used to register the atlas with the x-ray image and optical photo. The accuracy of the atlas registration was evaluated by comparing the registered atlas with the organ-labeled micro-CT images of the test subjects. The results showed excellent registration accuracy of the whole-body region, and good accuracy for the brain, liver, heart, lungs and kidneys. In its implementation, the MARS system was integrated with a preclinical PET scanner to deliver combined PET/MARS imaging, and to facilitate atlas-assisted analysis of the preclinical PET images.
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影响因子:
3.1
作者:
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通讯作者:
Lelieveldt, Boudewijn P. F.
影响因子:
1.4
作者:
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通讯作者:
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影响因子:
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作者:
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通讯作者:
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影响因子:
3.8
作者:
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通讯作者:
Wang, Hongkai
影响因子:
2.8
作者:
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通讯作者:
Nalcioglu, Orhan