Adaptive Deep Brain Stimulation for sleep stage targeting in Parkinson's disease.
Adaptive Deep Brain Stimulation for sleep stage targeting in Parkinson's disease.
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DOI：
10.1016/j.brs.2023.08.006
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发表时间：
2023-09
影响因子：
7.7
通讯作者：
Little, Simon
中科院分区：
文献类型：
--
作者：
Smyth, Clay;Anjum, Md Fahim;Ravi, Shravanan;Denison, Timothy;Starr, Philip;Little, Simon
睡眠功能障碍是帕金森病患者的致残因素，与运动和非运动结果的恶化有关。睡眠特异性自适应脑深部电刺激具有针对睡眠病理生理学的潜力。开发自适应脑深部电刺激算法，根据颅内分类的睡眠阶段调节刺激参数。我们在家中进行了多夜颅内皮层电图和多导睡眠图记录，以训练个性化的线性分类器来区分N3 NREM睡眠阶段。将分类器嵌入研究用脑深部电刺激器，用于N3特定自适应DBS。我们报告了两名参与者的嵌入式自主颅内皮质电图N3睡眠阶段分类的高度特异性，并提供了成功的睡眠阶段特异性自适应脑深部电刺激的原理证明。多夜皮质基底记录和睡眠特异性自适应脑深部电刺激提供了一个实验框架，以研究睡眠病理生理学和与刺激的机械相互作用，从而开发直接针对睡眠功能障碍的治疗性神经刺激范例。
Sleep dysfunction is disabling in people with Parkinson’s disease and is linked to worse motor and non-motor outcomes. Sleep-specific adaptive Deep Brain Stimulation has the potential to target pathophysiologies of sleep. Develop an adaptive Deep Brain Stimulation algorithm that modulates stimulation parameters in response to intracranially classified sleep stages. We performed at-home, multi-night intracranial electrocorticography and polysomnogram recordings to train personalized linear classifiers for discriminating the N3 NREM sleep stage. Classifiers were embedded into investigational Deep Brain Stimulators for N3 specific adaptive DBS. We report high specificity of embedded, autonomous, intracranial electrocorticography N3 sleep stage classification across two participants and provide proof-of-principle of successful sleep stage specific adaptive Deep Brain Stimulation. Multi-night cortico-basal recordings and sleep specific adaptive Deep Brain Stimulation provide an experimental framework to investigate sleep pathophysiology and mechanistic interactions with stimulation, towards the development of therapeutic neurostimulation paradigms directly targeting sleep dysfunction.
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晚期帕金森病的自适应深脑刺激。
影响因子：
11.2
作者：
Little, Simon;Pogosyan, Alex;Neal, Spencer;Zavala, Baltazar;Zrinzo, Ludvic;Hariz, Marwan;Foltynie, Thomas;Limousin, Patricia;Ashkan, Keyoumars;FitzGerald, James;Green, Alexander L.;Aziz, Tipu Z.;Brown, Peter
通讯作者：
Brown, Peter
影响因子：
8.6
作者：
Barone, Paolo;Antonini, Angelo;Del Dotto, Paolo
通讯作者：
Del Dotto, Paolo
影响因子：
6
作者：
Monaca, C;Ozsancak, C;Derambure, P
通讯作者：
Derambure, P
帕金森氏病患者的回路发现和适应性刺激的神经记录的长期无线流媒体流。
影响因子：
46.9
作者：
Gilron R;Little S;Perrone R;Wilt R;de Hemptinne C;Yaroshinsky MS;Racine CA;Wang SS;Ostrem JL;Larson PS;Wang DD;Galifianakis NB;Bledsoe IO;San Luciano M;Dawes HE;Worrell GA;Kremen V;Borton DA;Denison T;Starr PA
通讯作者：
Starr PA
影响因子：
6.1
作者：
Verma, Ajay K.;Yu, Ying;Acosta-Lenis, Sergio F.;Havel, Tyler;Sanabria, David Escobar;Molnar, Gregory F.;MacKinnon, Colum D.;Howell, Michael J.;Vitek, Jerrold L.;Johnson, Luke A.
通讯作者：
Johnson, Luke A.