CDKN1A-interacting zinc finger protein 1 is a novel biomarker for lung squamous cell carcinoma.
CDKN1A-interacting zinc finger protein 1 is a novel biomarker for lung squamous cell carcinoma.
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CDKN1A 相互作用的锌指蛋白 1 是肺鳞状细胞癌的新型生物标志物
DOI：
10.3892/ol.2017.7282
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发表时间：
2018-01
期刊：
影响因子：
2.9
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Zhou X;Liu Q;Wada Y;Liao L;Liu J
CDKN 1A相互作用锌指蛋白1（CIZ 1）是一种参与DNA复制的核蛋白，参与多种类型癌症的发病机制。然而，CIZ 1在肺鳞状细胞癌（LSCC）中的作用尚未完全了解。在本研究中，CIZ 1的表达在组织芯片和手术样本的人LSCC进行了检查。与邻近组织或正常对照相比，发现CIZ 1表达在LSCC组织中显著增加，而CIZ 1相互作用蛋白p21 Cip 1/Waf 1的表达降低。CIZ 1染色强度和CIZ 1阳性血管浸润与至少两种肿瘤-淋巴结-转移（TNM）分期系统（T分期、N分期或TNM分期）呈正相关。CIZ 1在喉鳞癌组织中的血管细胞中特异性表达。这些结果表明，CIZ 1的过表达可能有助于LSCC的生长和血管生成，因此CIZ 1可能代表诊断的生物标志物和治疗干预的靶点。
CDKN1A-interacting zinc finger protein 1 (CIZ1), a nuclear protein that participates in DNA replication, is involved in the pathogenesis of several types of cancer. However, the role of CIZ1 in lung squamous cell carcinoma (LSCC) is not fully understood. In the present study, the expression of CIZ1 in tissue microarrays and surgical samples of human LSCCs was examined. CIZ1 expression was found to be significantly increased in LSCC tissues compared with adjacent tissues or normal controls, whereas expression of a CIZ1-interacting protein, p21Cip1/Waf1, was decreased. CIZ1 staining intensity and CIZ1-positive vascular invasion were positively correlated with at least two categories of the Tumor-Node-Metastasis (TNM) staging system (T stage, N stage or TNM stage). It was also observed that CIZ1 was specifically expressed in the vascular cells of LSCC tissues. These results indicate that overexpression of CIZ1 may contribute to the growth and angiogenesis of LSCC, thus CIZ1 could represent a biomarker for diagnosis and a target for therapeutic intervention.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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通讯作者：
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影响因子：
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作者：
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