Molecular regulation of skeletal muscle mass

Molecular regulation of skeletal muscle mass
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骨骼肌质量的分子调节

DOI:
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发表时间:
2010
影响因子:
2.9
通讯作者:
Aaron P Russell
Aaron P Russell
中科院分区:
医学4区
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--
作者:
Aaron P Russell

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1.骨骼肌质量的维持取决于蛋白质合成和蛋白质降解之间的良好平衡。当蛋白质合成净增加时,骨骼质量增加,这可能发生在渐进式运动训练之后。相比之下,骨骼肌质量损失时,降解发生比合成更快,并观察到在许多条件下,包括神经肌肉疾病,慢性疾病,衰老,以及以下肢体固定或长期卧床休息由于受伤或创伤。
1. The maintenance of skeletal muscle mass is determined by a fine balance between protein synthesis and protein degradation. Skeletal mass is increased when there is a net gain in protein synthesis, which can occur following progressive exercise training. In contrast, skeletal muscle mass is lost when degradation occurs more rapidly than synthesis and is observed in numerous conditions, including neuromuscular disease, chronic disease, ageing, as well as following limb immobilization or prolonged bed rest due to injury or trauma.
SRF 蛋白在拉伸引起的公鸡 ALD 肌肉肥大过程中上调。
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发表时间: 1999
期刊: Journal of applied physiology (Bethesda, Md. : 1985)
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