The Role of Elastin in Wound Healing and Dermal Substitute Design

The Role of Elastin in Wound Healing and Dermal Substitute Design
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弹性蛋白在伤口愈合和真皮替代品设计中的作用

DOI:
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发表时间:
2013
期刊:
影响因子:
--
通讯作者:
A. Weiss
A. Weiss
中科院分区:
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文献类型:
--
作者:
J. Rnjak‐Kovacina;A. Weiss

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弹性蛋白占人体皮肤真皮层干重的2 - 4%,尽管其丰度相对较低,但它起着主要的结构、机械和细胞信号传导作用(图5.1)(Vrhovski和Weiss 1998)。弹性纤维网络的完整性是皮肤弹性、回弹性、质量和质地的重要决定因素(Kielty 2006; Roten et al. 1996)。它的重要性尤其体现在各种影响真皮弹性蛋白表达的遗传疾病(如皮肤松弛症和弹性假性黄瘤)中皮肤损伤的严重性(Kielty 2006)。
Elastin makes up 2–4 % of the dry weight of the human skin dermis, yet despite its relatively low abundance, it serves major structural, mechanical, and cell-signaling roles (Fig. 5.1) (Vrhovski and Weiss 1998). The integrity of the elastic fiber network is a strong determinant of the skin’s elasticity, resilience, quality, and texture (Kielty 2006; Roten et al. 1996). Its importance is particularly exemplified by the severity of skin impairment in various genetic disorders that affect elastin expression in the dermis, such as cutis laxa and pseudoxanthoma elasticum (Kielty 2006).
DOI: --
发表时间: 1989
期刊: Laboratory investigation; a journal of technical methods and pathology
影响因子: --
作者:
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期刊: BIOMATERIALS
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