Listeria and Salmonella bacterial vectors of tumor-associated antigens for cancer immunotherapy.
Listeria and Salmonella bacterial vectors of tumor-associated antigens for cancer immunotherapy.
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DOI：
10.1016/j.smim.2010.02.002
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发表时间：
2010-06
影响因子：
7.8
通讯作者：
Wood LM
中科院分区：
文献类型：
--
作者：
Paterson Y;Guirnalda PD;Wood LM
本综述涵盖了兼性细胞内细菌、单核细胞增生李斯特氏菌和鼠伤寒沙门氏菌作为肿瘤免疫治疗中肿瘤相关抗原的递送系统的用途。由于它们能够感染抗原呈递细胞并在其中存活，这些细菌已被用来将肿瘤抗原以细菌表达的蛋白质和在真核质粒上编码的形式递送至免疫系统。他们在强大的先天免疫的背景下做到这一点，这为免疫反应提供了所需的刺激，以打破对那些与自身具有同源性的肿瘤相关抗原的耐受性。在这里，我们描述了这些细菌作为疫苗载体的特性差异，总结了它们所应用的主要疗法及其临床进展。
This review covers the use of the facultative intracellular bacteria, Listeria monocytogenes and Salmonella enterica serovar typhimurium as delivery systems for tumor-associated antigens in tumor immunotherapy. Because of their ability to infect and survive in antigen presenting cells, these bacteria have been harnessed to deliver tumor antigens to the immune system both as bacterially expressed proteins and encoded on eukaryotic plasmids. They do this in the context of strong innate immunity, which provides the required stimulus to the immune response to break tolerance against those tumor-associated antigens that bear homology to self. Here we describe differences in the properties of these bacteria as vaccine vectors, a summary of the major therapies they have been applied to and their advancement towards the clinic.
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