Albuminuria is associated with too few glomeruli and too much testosterone.
Albuminuria is associated with too few glomeruli and too much testosterone.
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DOI：
10.1038/ki.2013.45
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发表时间：
2013-06
影响因子：
19.6
通讯作者：
中科院分区：
文献类型：
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作者：
正常情况下，肾小球滤过屏障几乎完全阻止循环白蛋白进入尿液。遗传变异和出生前和出生后的环境因素可能会影响人类的蛋白尿。在这里，我们确定是否肾小球基因表达的小鼠品系与自然发生的白蛋白尿的变化将允许鉴定蛋白质失调相对'渗漏'肾小球。从雌性B6到雄性B6到雌性FVB/N再到雄性FVB/N小鼠，白蛋白尿增加，而肾小球/肾脏数量正好相反。替莫昔单抗给药导致雌性B6小鼠的白蛋白尿增加，但雌性FVB/N小鼠的白蛋白尿没有增加。一组常见的39种基因（许多在足细胞中表达）在四种比较中的每一种中均显著差异表达：雄性与雌性B6小鼠、雄性与雌性FVB/N小鼠、雄性FVB/N与雄性B6小鼠和雌性FVB/N与雌性B6小鼠。转录本编码参与氧化/还原反应、离子转运和解毒酶的蛋白质。这些蛋白质可能代表新的生物标志物，甚至是早期肾脏和心血管疾病的治疗靶点。
Normally, the glomerular filtration barrier almost completely excludes circulating albumin from entering the urine. Genetic variation and both pre- and postnatal environmental factors may affect albuminuria in humans. Here we determine whether glomerular gene expression in mouse strains with naturally occurring variations in albuminuria would allow identification of proteins deregulated in relatively ‘leaky' glomeruli. Albuminuria increased in female B6 to male B6 to female FVB/N to male FVB/N mice, whereas the number of glomeruli/kidney was the exact opposite. Testosterone administration led to increased albuminuria in female B6 but not female FVB/N mice. A common set of 39 genes, many expressed in podocytes, were significantly differentially expressed in each of the four comparisons: male versus female B6 mice, male versus female FVB/N mice, male FVB/N versus male B6 mice, and female FVB/N versus female B6 mice. The transcripts encoded proteins involved in oxidation/reduction reactions, ion transport, and enzymes involved in detoxification. These proteins may represent novel biomarkers and even therapeutic targets for early kidney and cardiovascular disease.
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影响因子：
13.2
作者：
Chen, A;Sheu, LF;Lee, WH
通讯作者：
Lee, WH
影响因子：
13.6
作者：
Amsellem, Sabine;Gburek, Jakub;Kozyraki, Renata
通讯作者：
Kozyraki, Renata
影响因子：
19.6
作者：
Doublier S;Lupia E;Catanuto P;Periera-Simon S;Xia X;Korach K;Berho M;Elliot SJ;Karl M
通讯作者：
Karl M
影响因子：
--
作者：
Bhat, GK;Sea, TL;Mann, DR
通讯作者：
Mann, DR
影响因子：
158.5
作者：
Barker, DJP;Osmond, C;Eriksson, JG
通讯作者：
Eriksson, JG