NLRP3 inflammasome: activation and regulation in age-related macular degeneration.
NLRP3 inflammasome: activation and regulation in age-related macular degeneration.
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DOI：
10.1155/2015/690243
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发表时间：
2015
影响因子：
4.6
通讯作者：
Matsubara JA
中科院分区：
文献类型：
--
作者：
Gao J;Liu RT;Cao S;Cui JZ;Wang A;To E;Matsubara JA
老年性黄斑变性(AMD)是工业化国家老年人法定失明的主要原因。AMD是一种受遗传和环境危险因素影响的多因素疾病。AMD的进展特征是玻璃体的数量和大小增加，细胞外沉积聚集在视网膜外部的视网膜色素上皮(RPE)和Bruchs膜(BM)之间。AMD早期的氧化应激和炎症反应是其发病的主要途径。这些机制之间的相互作用推动AMD从早期向晚期过渡，如地理萎缩(GA)或脉络膜新生血管(CNV)，人们对此知之甚少。作为先天免疫系统的一部分，炎症小体激活在RPE细胞中被发现，并被认为是RPE功能障碍和退变的原因因素。在这里，我们将首先回顾经典的炎性小体激活模型，然后讨论AMD相关因子在非眼免疫细胞和RPE细胞中激活炎性小体的潜力，最后介绍几种新的调控炎性小体活性的机制。
Age-related macular degeneration (AMD) is the leading cause of legal blindness in the elderly in industrialized countries. AMD is a multifactorial disease influenced by both genetic and environmental risk factors. Progression of AMD is characterized by an increase in the number and size of drusen, extracellular deposits, which accumulate between the retinal pigment epithelium (RPE) and Bruch's membrane (BM) in outer retina. The major pathways associated with its pathogenesis include oxidative stress and inflammation in the early stages of AMD. Little is known about the interactions among these mechanisms that drive the transition from early to late stages of AMD, such as geographic atrophy (GA) or choroidal neovascularization (CNV). As part of the innate immune system, inflammasome activation has been identified in RPE cells and proposed to be a causal factor for RPE dysfunction and degeneration. Here, we will first review the classic model of inflammasome activation, then discuss the potentials of AMD-related factors to activate the inflammasome in both nonocular immune cells and RPE cells, and finally introduce several novel mechanisms for regulating the inflammasome activity.
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影响因子：
29.7
作者：
Davis BK;Wen H;Ting JP
通讯作者：
Ting JP
影响因子：
11.4
作者：
Aliprantis, AO;Yang, RB;Zychlinsky, A
通讯作者：
Zychlinsky, A
影响因子：
--
作者：
CRUICKSHANKS, KJ;KLEIN, R;KLEIN, BEK
通讯作者：
KLEIN, BEK
DOI：
10.1073/pnas.222551899
发表时间：
2002-11-12
影响因子：
11.1
作者：
Crabb, JW;Miyagi, M;Hollyfield, JG
通讯作者：
Hollyfield, JG
影响因子：
13.7
作者：
Chew EY;Clemons TE;Agrón E;Sperduto RD;Sangiovanni JP;Kurinij N;Davis MD;Age-Related Eye Disease Study Research Group
通讯作者：
Age-Related Eye Disease Study Research Group