CD36 deficiency affects depressive-like behaviors possibly by modifying gut microbiota and the inflammasome pathway in mice.
CD36 deficiency affects depressive-like behaviors possibly by modifying gut microbiota and the inflammasome pathway in mice.
复制标题
CD36 缺乏可能通过改变小鼠的肠道微生物群和炎症小体通路来影响抑郁样行为。
DOI：
10.1038/s41398-020-01130-8
复制
发表时间：
2021-01-05
影响因子：
6.8
通讯作者：
Xie P
中科院分区：
文献类型：
--
作者：
Bai S;Wang W;Wang T;Li J;Zhang S;Chen Z;Qi X;Chen J;Cheng K;Xie P
炎症过程和肠道微生物区系都与抑郁症的病理生理学有关。B类清道夫受体CD36参与炎症相关的细胞毒性。然而，它在抑郁症中的作用还没有被研究。在这项研究中，我们研究了CD36是否通过调节微生物区系-肠道-炎症体-脑轴来影响抑郁症。我们使用了处于慢性社会失败应激状态的−/−(基因敲除)小鼠，并检测了这些抑郁小鼠和抑郁症患者中CD36的表达。以−/−小鼠海马区为研究对象，研究NLRP3炎症体信号通路的变化。采用基于16SRRNA基因序列的方法对CD36、−/−和WT小鼠盲肠微生物群落进行了比较。CD36缺陷的−/−小鼠可减轻慢性应激诱导的抑郁样行为。CD36在抑郁小鼠和抑郁患者中表达上调。此外，NLRP3炎症体信号通路在−/−小鼠海马区表达下调。辛普森多样性指数显示CD36−/−小鼠盲肠细菌α多样性增加。在属中，类杆菌、里克氏杆菌和别杆菌在CD36−/−小鼠中显著丰富，而Allobaculum则较少，这与CD36−/−小鼠海马区的炎症减轻相一致。我们的发现表明，CD36缺乏改变了肠道微生物区系组成，进而可能通过影响炎症小体途径影响抑郁样行为。
Both inflammatory processes and gut microbiota have been implicated in the pathophysiology of depressive disorders. The class B scavenger receptor CD36 is involved in the cytotoxicity associated with inflammation. However, its role in depression has not yet been examined. In this study, we investigated whether CD36 affects depression by modulating the microbiota-gut-inflammasome-brain axis. We used CD36−/− (knockout) mice subjected to chronic social defeat stress, and measured the expression of CD36 in these depressed mice and in patients with depression. The hippocampus of CD36−/− mice was used to investigate changes in the NLRP3 inflammasome signaling pathway. The 16S rRNA gene sequence-based approach was used to compare the cecal microbial communities in CD36−/− and WT mice. The CD36 deficiency in CD36−/− mice alleviated chronic stress-induced depression-like behaviors. CD36 was upregulated in depressed mice as well as in depressed patients. Furthermore, the NLRP3 inflammasome signaling pathway was downregulated in the hippocampus of CD36−/− mice. The Simpson Diversity Index revealed increased cecal bacterial alpha-diversity in the CD36−/− mice. Among genera, Bacteroides, Rikenella, and Alloprevotella were significantly more abundant in the CD36−/− mice, whereas Allobaculum was less abundant, consistent with the attenuated inflammation in the hippocampus of CD36−/− mice. Our findings suggest that CD36 deficiency changes the gut microbiota composition, which in turn may impact depressive-like behaviors by affecting the inflammasome pathway.
登录
查看更多内容
DOI：
10.1083/jcb.138.3.707
发表时间：
1997-08-11
期刊：
The Journal of cell biology
影响因子：
--
作者：
Dawson DW;Pearce SF;Zhong R;Silverstein RL;Frazier WA;Bouck NP
通讯作者：
Bouck NP
星形胶质细胞中NLRP3炎症小体的解偶联蛋白2调节及其对抑郁症的影响
影响因子：
11.4
作者：
Du, Ren-Hong;Wu, Fang-Fang;Lu, Ming;Shu, Xiao-dong;Ding, Jian-Hua;Wu, Guangyu;Hu, Gang
通讯作者：
Hu, Gang
影响因子：
4.2
作者：
Galley JD;Nelson MC;Yu Z;Dowd SE;Walter J;Kumar PS;Lyte M;Bailey MT
通讯作者：
Bailey MT
海马体的综合代谢组学和脂质组学分析揭示了慢性不可预测的轻度应激性抑郁症大鼠模型中的代谢生物标志物
影响因子：
--
作者：
Geng, Chunmei;Qiao, Yi;Jiang, Pei
通讯作者：
Jiang, Pei
影响因子：
5.1
作者：
Alcocer-Gomez, Elisabet;Ulecia-Moron, Cristina;Cordero, Mario D.
通讯作者：
Cordero, Mario D.