Prophylactic cancer vaccination by targeting functional non-self.
Prophylactic cancer vaccination by targeting functional non-self.
复制标题
通过针对功能性非自我进行预防性癌症疫苗接种。
DOI：
10.3109/07853890.2011.565065
复制
发表时间：
2011-08
影响因子：
4.4
通讯作者：
Jaini R
中科院分区：
文献类型：
--
作者：
Tuohy VK;Jaini R
尽管儿童预防性疫苗接种取得了巨大成功，但没有类似的计划旨在为我们随着年龄的增长提供针对乳腺癌等成人发病疾病的保护。相反，目前癌症疫苗策略的主要重点是在肿瘤形成后接种疫苗。这种策略最多只能提供总体生存率的增量改善。我们建议制定一个成人疫苗接种计划，以儿童计划为模型，为我们进入中年时所面临的疾病提供保护。由于大多数成人癌症病例与明确的致病病毒无关，我们建议将疫苗靶点的选择扩展到组织特异性自身蛋白，这些蛋白在发展中的肿瘤中过表达，但在正常组织中不再表达（“退休或以前的自我”），在正常组织中表达，（“条件性自我”），或不能靶向任何临床显著的自身免疫并发症（“不相关的自我”）。通过将预防性疫苗接种扩展到这种“功能性非自身”，针对成年发病疾病（如乳腺癌）的预防性疫苗接种可以在没有任何自身免疫性炎症并发症的情况下安全地发生，并且可能以模仿儿童疫苗接种对麻疹和脊髓灰质炎等疾病的影响的方式降低疾病发病率。
Despite the monumental success of childhood prophylactic vaccination, there is no similar program designed to provide protection as we age against adult onset diseases like breast cancer. Instead, the predominant focus of current cancer vaccine strategy is to vaccinate after the tumors become established. This strategy has at best provided incremental improvement in overall survival. We propose the development of an adult vaccination program modeled on the childhood program that provides protection against diseases we confront as we enter our middle age. Since most cases of adult cancers are not associated with definitive etiopathogenic viruses, we propose extending our selection of vaccine targets to tissue specific self proteins that are overexpressed in developing tumors but are no longer expressed in normal tissues ('retired or former self'), are expressed in normal tissues under readily avoidable conditions ('conditional self'), or are incapable of targeting any clinically significant autoimmune complications ('irrelevant self'). By extending prophylactic vaccination to such 'functional non-self', prophylactic vaccination against adult onset diseases like breast cancer may occur safely in the absence of any autoimmune inflammatory complications and may potentially reduce disease incidence in a manner that mimics the impact of childhood vaccination on diseases like measles and polio.
登录
查看更多内容
DOI：
10.1056/nejmoa1003466
发表时间：
2010-08-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hodi FS;O'Day SJ;McDermott DF;Weber RW;Sosman JA;Haanen JB;Gonzalez R;Robert C;Schadendorf D;Hassel JC;Akerley W;van den Eertwegh AJ;Lutzky J;Lorigan P;Vaubel JM;Linette GP;Hogg D;Ottensmeier CH;Lebbé C;Peschel C;Quirt I;Clark JI;Wolchok JD;Weber JS;Tian J;Yellin MJ;Nichol GM;Hoos A;Urba WJ
通讯作者：
Urba WJ
影响因子：
1.7
作者：
Harper, Diane M.
通讯作者：
Harper, Diane M.
影响因子：
5.1
作者：
Anderson, LM;Swaminathan, S;Weitzman, SA
通讯作者：
Weitzman, SA
影响因子：
7.3
作者：
BAILEY, AJ;SLOANE, JP;ORMEROD, MG
通讯作者：
ORMEROD, MG
影响因子：
32.4
作者：
Harrington, CJ;Paez, A;Goverman, J
通讯作者：
Goverman, J