Photodynamic activity of C70 caged within surface-cross-linked liposomes.
Photodynamic activity of C70 caged within surface-cross-linked liposomes.
复制标题
表面交联脂质体中 C70 的光动力活性。
DOI：
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
T. Takeya
中科院分区：
文献类型：
--
作者：
A. Ikeda;Mai Nagano;Motofusa Akiyama;M. Matsumoto;S. Ito;Masaru Mukai;Mineo Hashizume;J. Kikuchi;Kiyofumi Katagiri;T. Ogawa;T. Takeya
[70]通过将C（70）γ-环糊精复合物掺入脂质膜的交换反应制备包封在表面交联脂质体（所谓的cerasome）中的富勒烯（C（70））。在25 ℃搅拌下，在1分钟内完成了在结合了神经酰胺酶体的C（70）（CIC（70））以及在结合了脂质膜的C（70）（LMIC（70））中的富勒烯交换。CIC（70）比LMIC（70）对裂解剂（如表面活性剂）的裂解更具抗性。此外，CIC（70）在HeLa细胞中的光动力学活性与LMIC（70）相似，表明C（70）可以作为光敏药物（PS）而不从神经酰胺酶体膜释放。因此，与需要从脂质体内部释放药物的一般药物递送系统（DDS）相比，用于光动力疗法（PDT）的PS的载体不一定需要释放药物。这些结果表明，具有高形态稳定性的DDS可以增加在血液中的停留时间，并通过增强的渗透性和保留（EPR）效应实现肿瘤选择性给药。
[70]Fullerene (C(70)) encapsulated into a surface-cross-linked liposome, a so-called cerasome, was prepared by an exchange reaction incorporating C(70)gamma-cyclodextrin complexes into lipid membranes. Fullerene exchange in a cerasome-incorporated C(70) (CIC(70)), as well as in a lipid-membrane-incorporated C(70) (LMIC(70)), was completed within 1 min with stirring at 25 degrees C. CIC(70) was more resistant to lysis than LMIC(70) towards lysing agents such as surfactants. Furthermore, the photodynamic activity of CIC(70) in HeLa cells was similar to that of LMIC(70), indicating that C(70) can act as a photosensitizing drug (PS) without release from cerasome membranes. Thus, in contrast with general drug-delivery systems (DDSs), which require the drug to be released from the interior of liposomes, carriers for PSs for use in photodynamic therapy (PDT) do not necessarily need to release the drug. These results indicate that DDSs with high morphological stability can increase the residence time in blood and achieves tumor-selective drug delivery by the enhanced permeability and retention (EPR) effect.
影响因子：
2.9
作者：
Miller, CR;Bondurant, B;O'Brien, DF
通讯作者：
O'Brien, DF
影响因子：
11.2
作者：
Y. Matsumura;H. Maeda
通讯作者：
Y. Matsumura;H. Maeda
DOI：
10.1073/pnas.84.21.7413
发表时间：
1987-11-01
影响因子：
11.1
作者：
FELGNER, PL;GADEK, TR;DANIELSEN, M
通讯作者：
DANIELSEN, M