Effect of hormone metabolism genotypes on steroid hormone levels and menopausal symptoms in a prospective population-based cohort of women experiencing the menopausal transition.
Effect of hormone metabolism genotypes on steroid hormone levels and menopausal symptoms in a prospective population-based cohort of women experiencing the menopausal transition.
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DOI：
10.1097/gme.0b013e3181db61a1
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发表时间：
2010-09
期刊：
影响因子：
--
通讯作者：
Freeman EW
中科院分区：
文献类型：
--
作者：
Rebbeck TR;Su HI;Sammel MD;Lin H;Tran TV;Gracia CR;Freeman EW
这项研究评估了参与类固醇激素代谢的基因是否与激素水平或更年期症状有关。我们采用以人群为基础的前瞻性样本，包括436名非裔美国人（AA）和欧裔美国人（EA）妇女，她们在入组时处于绝经前，并在绝经期间进行纵向随访。我们评估了COMT、CYP1A2、CYP1B1、CYP3A4、CYP19、SULT1A1和SULT1E1的类固醇激素代谢基因型与激素水平和更年期特征的关系。在EA女性中，与不携带这些变异等位基因的女性相比，SULT1E1变异携带者的硫酸脱氢表雄酮水平较低，SULT1A1变异携带者的雌二醇、硫酸脱氢表雄酮和睾酮水平较低。在AA女性中，CYP1B1*3基因型与潮热相关（优势比[OR]， 0.62; 95% CI, 0.40-0.95）。CYP1A2基因型的相互作用与绝经期潮热相关（P = 0.006）。CYP1B1*3 （P = 0.02）和CYP1B1*4 （P = 0.03）与绝经期的相互作用与抑郁症状相关。在EA女性中，SULT1A1*3与抑郁症状（OR, 0.53; 95% CI, 0.41-0.68）和潮热（OR, 2.08; 95% CI, 1.64-2.63）相关。SULT1A1*3与更年期潮热之间存在显著的相互作用（P < 0.001）， SULT1A1*2与抑郁症状之间存在显著的相互作用（P = 0.007），并且SULT1A1*2、SULT1A1*3、CYP1B1*3和CYP3A4*1B对更年期的影响存在种族特异性。我们的研究结果表明，基因型与绝经相关症状的发生或更年期过渡的时间有关。
This study evaluated whether genes involved in the metabolism of steroid hormones are associated with hormone levels or menopausal symptoms. We used a population-based prospective sample of 436 African American (AA) and European American (EA) women who were premenopausal at enrollment and were followed longitudinally through menopause. We evaluated the relationship between steroid hormone metabolism genotypes at COMT, CYP1A2, CYP1B1, CYP3A4, CYP19, SULT1A1, and SULT1E1 with hormone levels and menopausal features. In EA women, SULT1E1 variant carriers had lower levels of dehydroepiandrosterone sulfate, and SULT1A1 variant carriers had lower levels of estradiol, dehydroepiandrosterone sulfate, and testosterone compared with women who did not carry these variant alleles. In AA women, CYP1B1*3 genotypes were associated with hot flashes (odds ratio [OR], 0.62; 95% CI, 0.40–0.95). Interactions of CYP1A2 genotypes were associated with hot flashes across menopausal stage (P = 0.006). Interactions of CYP1B1*3 (P = 0.02) and CYP1B1*4 (P = 0.03) with menopausal stage were associated with depressive symptoms. In EA women, SULT1A1*3 was associated with depressive symptoms (OR, 0.53; 95% CI, 0.41–0.68) and hot flashes (OR, 2.08; 95% CI, 1.64–2.63). There were significant interactions between SULT1A1*3 and hot flashes (P < 0.001) and between SULT1A1*2 and depressive symptoms (P = 0.007) on menopausal stage, and there were race-specific effects of SULT1A1*2, SULT1A1*3, CYP1B1*3, and CYP3A4*1B on menopause. Our results suggest that genotypes are associated with the occurrence of menopause-related symptoms or the timing of the menopausal transition.
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影响因子：
3.8
作者：
Tworoger, SS;Chubak, J;McTiernan, A
通讯作者：
McTiernan, A
DOI：
10.1097/01.gme.0000227058.70903.9f
发表时间：
2006-11-01
影响因子：
2.7
作者：
Woods, Nancy F.;Mitchell, Ellen Sullivan;Farin, Federico M.
通讯作者：
Farin, Federico M.
影响因子：
5.9
作者：
Sowers, MaryFran R.;Wilson, Angela L.;McConnell, Daniel S.
通讯作者：
McConnell, Daniel S.
DOI：
10.1089/152460901750067133
发表时间：
2001-01-01
期刊：
JOURNAL OF WOMENS HEALTH & GENDER-BASED MEDICINE
影响因子：
--
作者：
Freeman, EW;Sammel, MD;Hollander, L
通讯作者：
Hollander, L
影响因子：
6.2
作者：
Napoli, N;Villareal, DT;Armamento-Villareal, R
通讯作者：
Armamento-Villareal, R