Influence of the TGF-β Superfamily on Osteoclasts/Osteoblasts Balance in Physiological and Pathological Bone Conditions.
Influence of the TGF-β Superfamily on Osteoclasts/Osteoblasts Balance in Physiological and Pathological Bone Conditions.
复制标题
TGF-β超家族对生理和病理性骨状况中破骨细胞/成骨细胞平衡的影响。
DOI：
10.3390/ijms21207597
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发表时间：
2020-10-14
影响因子：
5.6
通讯作者：
Faucheux N
中科院分区：
文献类型：
--
作者：
Jann J;Gascon S;Roux S;Faucheux N
骨形成细胞（成骨细胞/骨细胞）和骨吸收细胞（破骨细胞）之间的平衡在组织稳态和骨修复中起着至关重要的作用。几种激素、细胞因子和生长因子-特别是TGF-β超家族的成员，如骨形态发生蛋白-不仅调节这些细胞的增殖、分化和功能，而且还协调它们之间的通信以确保适当的反应。本文就TGF-β超家族及其通过调节破骨细胞生成、干细胞向成骨细胞分化、成骨细胞/破骨细胞平衡等对骨形成和修复的影响作一综述。在介绍了骨细胞的主要类型后，讨论了骨重建和骨折愈合过程中骨细胞的分化和协作。然后，TGF-β超家族，其通过经典和非经典途径的信号传导，以及Wnt/Notch或microRNA对其的调节进行了描述和讨论。其在骨稳态、修复或疾病中的重要作用也被强调。最后，TGF-β超家族成员的临床治疗用途及其相关并发症进行了辩论。
The balance between bone forming cells (osteoblasts/osteocytes) and bone resorbing cells (osteoclasts) plays a crucial role in tissue homeostasis and bone repair. Several hormones, cytokines, and growth factors—in particular the members of the TGF-β superfamily such as the bone morphogenetic proteins—not only regulate the proliferation, differentiation, and functioning of these cells, but also coordinate the communication between them to ensure an appropriate response. Therefore, this review focuses on TGF-β superfamily and its influence on bone formation and repair, through the regulation of osteoclastogenesis, osteogenic differentiation of stem cells, and osteoblasts/osteoclasts balance. After introducing the main types of bone cells, their differentiation and cooperation during bone remodeling and fracture healing processes are discussed. Then, the TGF-β superfamily, its signaling via canonical and non-canonical pathways, as well as its regulation by Wnt/Notch or microRNAs are described and discussed. Its important role in bone homeostasis, repair, or disease is also highlighted. Finally, the clinical therapeutic uses of members of the TGF-β superfamily and their associated complications are debated.
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影响因子：
64.5
作者：
Antebi YE;Linton JM;Klumpe H;Bintu B;Gong M;Su C;McCardell R;Elowitz MB
通讯作者：
Elowitz MB
影响因子：
7
作者：
Ahmed, Y. A.;Tatarczuch, L.;Mackie, E. J.
通讯作者：
Mackie, E. J.
DOI：
10.1007/s10555-016-9605-5
发表时间：
2016-03
期刊：
Cancer metastasis reviews
影响因子：
--
作者：
Bodenstine TM;Chandler GS;Seftor RE;Seftor EA;Hendrix MJ
通讯作者：
Hendrix MJ
影响因子：
4
作者：
Ashley JW;Ahn J;Hankenson KD
通讯作者：
Hankenson KD
影响因子：
4
作者：
Balemans, W;Patel, N;Van Hul, W
通讯作者：
Van Hul, W