What does the ratio of injected current to electrode area tell us about current density in the brain during tDCS?
What does the ratio of injected current to electrode area tell us about current density in the brain during tDCS?
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DOI：
10.1016/j.clinph.2009.03.023
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发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Hallett M
中科院分区：
文献类型：
--
作者：
Miranda PC;Faria P;Hallett M
目的：探讨经颅直流电刺激（tDCS）过程中脑内电极下固定靶点电流密度与注入电流与电极面积比值（I/A）的关系。用数值方法计算了标准球形头模型和均匀圆柱形导体中的电流密度分布。使用圆柱模型的计算表明，对于相同的I/A比，对于两个电极中较小的电极，在电极下方固定深度处的电流密度较低。使用球形模型，在电极下的大脑中的固定目标点处的电流密度被发现是I/A比的非线性函数。对于较小的电极，需要比I/A比预测的更多的电流来实现大脑中的预定电流密度。在大脑中的固定目标点处，注入电流、电极面积和电流密度之间存在非线性关系，这可以用导联特异性I-A曲线来描述。当调整不同电极尺寸的电流或比较不同电流-电极面积组合的影响时，应使用使用实际头部模型计算的或实验获得的I-A曲线。
To examine the relationship between the ratio of injected current to electrode area (I/A) and the current density at a fixed target point in the brain under the electrode during transcranial direct current stimulation (tDCS). Numerical methods were used to calculate the current density distribution in a standard spherical head model as well as in a homogeneous cylindrical conductor. The calculations using the cylindrical model showed that, for the same I/A ratio, the current density at a fixed depth under the electrode was lower for the smaller of the two electrodes. Using the spherical model, the current density at a fixed target point in the brain under the electrode was found to be a non-linear function of the I/A ratio. For smaller electrodes, more current than predicted by the I/A ratio was required to achieve a predetermined current density in the brain. A non-linear relationship exists between the injected current, the electrode area and the current density at a fixed target point in the brain, which can be described in terms of a montage-specific I–A curve. I-A curves calculated using realistic head models or obtained experimentally should be used when adjusting the current for different electrode sizes or when comparing the effect of different current - electrode area combinations.
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