In vitro functions of neutrophils induced by treatment with rhG‐CSF in severe congenital neutropenia
In vitro functions of neutrophils induced by treatment with rhG‐CSF in severe congenital neutropenia
复制标题
rhG-CSF治疗严重先天性中性粒细胞减少症诱导的中性粒细胞的体外功能
DOI：
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发表时间：
1991
影响因子：
3.1
通讯作者：
K. Welte
中科院分区：
文献类型：
--
作者：
J. Roesler;A. Emmendörffer;J. Eisner;C. Zeidler;M. Lohmann‐Matthes;K. Welte
Neutrophils (and monocytes) from 5 patients suffering from severe congenital neutropenia (SCN) were investigated in vitro after induction of this cell type by treatment with recombinant human granulocyte colony‐stimulating factor (rh G‐CSF) in vivo. Some abnormal morphological features were seen, such as anomalies of nuclei of phagocytes. No limitations were found 1) in the ability of neutrophils and monocytes to produce reactive oxygen intermediates (ROI) following stimulation with phorbolmyristate‐acetate (PMA), 2) in the ability of neutrophils to phagocytose particles of zymosan A and to produce ROI simultaneously and 3) in the ability to kill bacteria of the species staphylococcus aureus. However the specific migration of neutrophils in a gradient of FMLP under soft agar was decreased to approximately 50% in all patients tested as compared to healthy controls. In addition, spontaneous motility was decreased in one patient. Nevertheless, the good clinical improvements of patients suffering from SCN after treatment with rh G‐CSF appeared to be due to induction of neutrophils displaying overall good functional activities with respect to natural defense.
影响因子：
158.5
作者：
BONILLA, MA;GILLIO, AP;OREILLY, RJ
通讯作者：
OREILLY, RJ
人粒细胞集落刺激因子对特发性中性粒细胞减少症患者的影响。
DOI：
10.1056/nejm198901053200107
发表时间：
1989
期刊：
The New England journal of medicine
影响因子：
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作者：
Jakubowski,AA;Souza,L;Kelly,F;Fain,K;Budman,D;Clarkson,B;Bonilla,MA;Moore,MA;Gabrilove,J
通讯作者：
Gabrilove,J