Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion.
Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion.
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聚（乳酸 - 乙醇）酸微球封装在Pluronic F-127中的延长平丁蛋白的递送，并改善了从脱髓鞘病变中的功能恢复。
DOI：
10.1016/j.biomaterials.2014.06.051
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发表时间：
2014-10
期刊：
影响因子：
14
通讯作者：
Horner, Philip J.
中科院分区：
文献类型：
--
作者：
Sellers, Drew L.;Kim, Tae Hee;Mount, Christopher W.;Pun, Suzie H.;Horner, Philip J.
Components of the blood have been proposed as potential therapeutic targets for improving cellular regeneration after injury and neurodegenerative disease. In this work, thrombin is shown to increase endogenous neural progenitor proliferation in the intact murine spinal cord. A local injection of heparin before a spinal cord injury reduces cell proliferation and astrogliogenesis associated with scarring. We sought to create depot-formulations of PLGA microsphere and Pluronic F-127 for sustained local delivery of two thrombin inhibitors, heparin and hirudin. Each hydrogel depot-formulation showed delayed drug release compared to microspheres or hydrogel alone. Animals with a lateral demyelination lesion showed a reduction in CD68+ macrophages when treated with hirudin-loaded PLGA/F-127 gels compared to control and heparin-treated animals. Moreover, hirudin-loaded materials showed an accelerated recovery in coordinated stepping and increased oligodendrocyte densities. Together, these data demonstrate that controlled delivery of hirudin accelerates functional recovery from a demyelination lesion in the spinal cord.
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影响因子：
3.7
作者：
Kwon SK;Kim HB;Song JJ;Cho CG;Park SW;Choi JS;Ryu J;Oh SH;Lee JH
通讯作者：
Lee JH
影响因子：
25
作者：
Miron, Veronique E.;Boyd, Amanda;Zhao, Jing-Wei;Yuen, Tracy J.;Ruckh, Julia M.;Shadrach, Jennifer L.;van Wijngaarden, Peter;Wagers, Amy J.;Williams, Anna;Franklin, Robin J. M.;Ffrench-Constant, Charles
通讯作者：
Ffrench-Constant, Charles
影响因子：
14.5
作者：
Fleming, Jennifer C.;Norenberg, Michael D.;Weaver, Lynne C.
通讯作者：
Weaver, Lynne C.
影响因子：
5.3
作者：
Loy, DN;Talbott, JF;Whittemore, SR
通讯作者：
Whittemore, SR
DOI：
10.1097/01.wcb.0000100062.36077.84
发表时间：
2004-02-01
影响因子：
6.3
作者：
Karabiyikoglu, M;Hua, Y;Xi, GH
通讯作者：
Xi, GH