Emerging biosensing technologies for improved diagnostics of COVID-19 and future pandemics.
Emerging biosensing technologies for improved diagnostics of COVID-19 and future pandemics.
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DOI：
10.1016/j.talanta.2020.121986
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发表时间：
2021-04-01
期刊：
影响因子：
6.1
通讯作者：
Li Z
中科院分区：
文献类型：
--
作者：
Chen L;Zhang G;Liu L;Li Z
诊断工具在抗击COVID-19和其他大流行病方面发挥着重要作用。现有的测试，如RT-qPCR，具有局限性，包括长测定时间、低通量、灵敏度不足和次优的便携性。新兴的生物传感技术有望开发出快速、高灵敏度和适用于即时检测的检测方法，这将大大促进COVID-19的检测。尽管如此，这种生物传感器在流行病中的实际应用尚未实现。在这篇综述中，我们使用新兴的生物传感技术整合了新开发的COVID-19诊断工具，并讨论了它们的应用前景。特别是，我们提出了基于传统和新兴生物传感方法的COVID-19核酸检测和抗体检测。然后，我们提供对现有挑战和潜在解决方案的看法。
Diagnostic tools play significant roles in the fight against COVID-19 and other pandemics. Existing tests, such as RT-qPCR, have limitations including long assay time, low throughput, inadequate sensitivity, and suboptimal portability. Emerging biosensing technologies hold the promise to develop tests that are rapid, highly sensitive, and suitable for point-of-care testing, which could significantly facilitate the testing of COVID-19. Despite that, practical applications of such biosensors in pandemics have yet to be achieved. In this review, we consolidate the newly developed diagnostic tools for COVID-19 using emerging biosensing technologies and discuss their application promise. In particular, we present nucleic acid tests and antibody tests of COVID-19 based on both conventional and emerging biosensing methods. We then provide perspectives on the existing challenges and potential solutions.
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