Sensitization of aortic and cardiac baroreceptors by arginine vasopressin in mammals.
Sensitization of aortic and cardiac baroreceptors by arginine vasopressin in mammals.
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精氨酸加压素对哺乳动物的主动脉和心脏压力感受器敏感。
DOI：
10.1113/jphysiol.1986.sp016185
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
B. N. Gupta
中科院分区：
文献类型：
--
作者：
F. Abboud;P. Aylward;J. Floras;B. N. Gupta
加压素有助于控制循环的压力感受器反射。该肽可能作用于多个部位，以增强压力感受器反射。在这项研究中，我们研究了加压素对麻醉兔的主动脉压力感受器和麻醉猫的左心室机械感受器的影响。加压素(16亩/公斤)Min)不改变主动脉压力感受器单纤维的静息神经放电。加压素(16亩/公斤)Min)可显著增强单个主动脉神经纤维放电对动脉压升高的反应。神经活动与平均动脉压之间的斜率从0.24+/-0.05(平均值+/-SEE)增加到0.50+/-0.16脉冲/心动周期。10根主动脉髓质纤维的脉冲值为0.06+/-0.03~0.18+/-0.04个/心动周期，P<0.05。MmHg(P<0.05)在三个非有髓纤维中。加压素(16亩/公斤)Min)不改变左心室机械感受器单纤维的静息神经放电。加压素(16亩/公斤)Min显著增强左心室机械感受器对左室舒张末压升高的单一神经纤维放电的反应。神经活动与左心室舒张末压力的斜率从0.24+/-0.07增加到0.32+/-0.07个/心动周期。6根有髓纤维的脉冲值为0.10+/-0.01~0.15+/-0.02次/心动周期，P<0.05。4根无髓纤维的MmHg值(P<0.05)。这些数据表明，加压素使高压和低压压力感受器敏感，并提示了加压素可能促进压力感受性反射控制循环的机制。
Vasopressin facilitates the baroreflex control of the circulation. The peptide may act at several sites to augment the baroreflex. In this study we examined the effect of vasopressin on aortic baroreceptors in anaesthetized rabbits and on left ventricular mechanoreceptors in anaesthetized cats. Vasopressin (16 mu./kg. min) did not change resting nerve discharge in single fibres from aortic baroreceptors. Vasopressin (16 mu./kg. min) significantly enhanced the response of single aortic nerve fibre discharge to elevation in arterial pressure. The slope relating nerve activity to mean arterial pressure increased from 0.24 +/‐ 0.05 (mean +/‐ S.E. of mean) to 0.50 +/‐ 0.16 impulses/cardiac cycle. mmHg (P less than 0.05) in ten aortic medullated fibres and from 0.06 +/‐ 0.03 to 0.18 +/‐ 0.04 impulses/cardiac cycle. mmHg (P less than 0.05) in three non‐medullated fibres. Vasopressin (16 mu./kg. min) did not change resting nerve discharge in single fibres from left ventricular mechanoreceptors. Vasopressin (16 mu./kg. min) significantly enhanced the response of single nerve fibre discharge from left ventricular mechanoreceptors in response to elevation of left ventricular end‐diastolic pressure. The slope relating nerve activity to left ventricular end‐diastolic pressure increased from 0.24 +/‐ 0.07 to 0.32 +/‐ 0.07 impulses/cardiac cycle. mmHg (P less than 0.05) in six medullated fibres and from 0.10 +/‐ 0.01 to 0.15 +/‐ 0.02 impulses/cardiac cycle. mmHg (P less than 0.05) in four non‐medullated fibres. These data show that vasopressin sensitizes high and low pressure baroreceptors and suggest a mechanism by which vasopressin may facilitate the baroreflex control of the circulation.
加压素对腰交感神经活动的压力感受反射抑制的对比作用。
DOI：
10.1152/ajpheart.1985.249.5.h922
发表时间：
1985
期刊：
The American journal of physiology
影响因子：
--
作者：
Sharabi,FM;Guo,GB;Abboud,FM;Thames,MD;Schmid,PG
通讯作者：
Schmid,PG