The influence of anesthesia and surgery on fear extinction
The influence of anesthesia and surgery on fear extinction
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麻醉和手术对恐惧消退的影响
DOI：
10.1016/j.neulet.2021.136347
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发表时间：
2021-11
影响因子：
2.5
通讯作者：
Xue-sheng Liu
中科院分区：
文献类型：
--
作者：
Xin Qing;Yuan-ling Xu;Hu Liu;Xue-sheng Liu
Accumulating evidence has demonstrated significant clinical post-traumatic stress disorder (PTSD) symptoms after anesthesia or surgery. Fear extinction dysfunction is a notable feature of PTSD. Although anesthetics and surgery profoundly affect memory processes, their designated effects on fear extinction have not been dissertated. Previous studies have suggested that innate immune system activation disrupts fear extinction, and surgery has been shown to increase the inflammatory response. Thus, in the current study, we examined the effects of propofol, sevoflurane, dexmedetomidine and surgery on fear extinction in adolescent mice, and further tested whether dexmedetomidine could reverse the injury effect of surgery on fear extinction through its anti-inflammatory effects. Our results showed that propofol (200 mg/kg) impaired the acquisition and recall of cued fear extinction, and surgery disrupted cued fear extinction acquisition/recall and consolidation. In contrast to cued fear extinction, contextual fear extinction was not affected by propofol or surgery. Moreover, dexmedetomidine prevented surgery-induced impairment of cued extinction acquisition and recall but not consolidation. Finally, TNF-α and IL-6 levels in the ventromedial prefrontal cortex were not necessary for the dexmedetomidine treatment effect of surgery-induced fear extinction dysfunction. The study results showed that propofol and surgery selective impaired the cued fear extinction stage in adolescent mice, and dexmedetomidine may unleash a protective effect in preventing postoperative PTSD.
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DOI：
10.1523/jneurosci.2251-18.2018
发表时间：
2018-12
期刊：
The Journal of Neuroscience
影响因子：
--
作者：
M. Morena;R. Aukema;Kira D Leitl;A. Rashid;H. A. Vecchiarelli;S. Josselyn;M. Hill
通讯作者：
M. Morena;R. Aukema;Kira D Leitl;A. Rashid;H. A. Vecchiarelli;S. Josselyn;M. Hill
影响因子：
5.2
作者：
G. Schelling;B. Roozendaal;T. Krauseneck;Martin Schmoelz;D. D. de Quervain-D.;J. Briegel
通讯作者：
G. Schelling;B. Roozendaal;T. Krauseneck;Martin Schmoelz;D. D. de Quervain-D.;J. Briegel
影响因子：
16.6
作者：
Luo R;Uematsu A;Weitemier A;Aquili L;Koivumaa J;McHugh TJ;Johansen JP
通讯作者：
Johansen JP
影响因子：
2.7
作者：
Morena, Maria;Berardi, Andrea;Campolongo, Patrizia
通讯作者：
Campolongo, Patrizia
影响因子：
5.3
作者：
Liu, Yu;Jean-Richard-dit-Bressel, Philip;McNally, Gavan P.
通讯作者：
McNally, Gavan P.