The Production of Pyruvate in Biological Technology: A Critical Review.
The Production of Pyruvate in Biological Technology: A Critical Review.
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生物技术中丙酮酸的生产：批判性评论
DOI：
10.3390/microorganisms10122454
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发表时间：
2022-12-12
期刊：
影响因子：
4.5
通讯作者：
Sun J
中科院分区：
文献类型：
--
作者：
Yuan W;Du Y;Yu K;Xu S;Liu M;Wang S;Yang Y;Zhang Y;Sun J
丙酮酸在食品、化学和制药工业中有许多应用。化学合成的高成本阻碍了丙酮酸盐在许多应用中的广泛使用。代谢工程和传统的突变和选择策略已经应用于微生物以提高其生产丙酮酸的能力。在过去的几十年中，产生了不同的微生物菌株以提高其丙酮酸生产能力。加之近年来基因工程和代谢工程的发展，野生型酵母、E。大肠杆菌等高产丙酮酸菌株的研究已成为热点。该策略和对与丙酮酸生产直接相关的中心代谢的理解可以为发酵产物的改进提供有价值的信息。本综述的目的之一是收集有关代谢工程菌株和用于高产和高效生产丙酮酸的微生物发酵过程的信息。
Pyruvic acid has numerous applications in the food, chemical, and pharmaceutical industries. The high costs of chemical synthesis have prevented the extensive use of pyruvate for many applications. Metabolic engineering and traditional strategies for mutation and selection have been applied to microorganisms to enhance their ability to produce pyruvate. In the past decades, different microbial strains were generated to enhance their pyruvate production capability. In addition to the development of genetic engineering and metabolic engineering in recent years, the metabolic transformation of wild-type yeast, E. coli, and so on to produce high-yielding pyruvate strains has become a hot spot. The strategy and the understanding of the central metabolism directly related to pyruvate production could provide valuable information for improvements in fermentation products. One of the goals of this review was to collect information regarding metabolically engineered strains and the microbial fermentation processes used to produce pyruvate in high yield and productivity.
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影响因子：
3.5
作者：
DESCOTES, J
通讯作者：
DESCOTES, J
麦角酵母菌通过改变甘油的吸收和分解途径，从这种被视为 "不可发酵 "的碳源中生成大量乙醇
影响因子：
6.3
作者：
Asskamp, Maximilian R.;Klein, Mathias;Nevoigt, Elke
通讯作者：
Nevoigt, Elke
影响因子：
4.1
作者：
Hollmann, R;Deckwer, WD
通讯作者：
Deckwer, WD
DOI：
10.1046/j.1432-1327.2001.02126.x
发表时间：
2001-04-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Maaheimo, H;Fiaux, J;Szyperski, T
通讯作者：
Szyperski, T
影响因子：
5
作者：
Kamzolova, Svetlana V.;Morgunov, Igor G.
通讯作者：
Morgunov, Igor G.