Generation of ramoplanin-resistant Staphylococcus aureus.
Generation of ramoplanin-resistant Staphylococcus aureus.
复制标题
耐雷莫拉宁金黄色葡萄球菌的产生。
DOI：
10.1111/j.1574-6968.2010.02051.x
复制
发表时间：
2010
影响因子：
2.1
通讯作者：
McCafferty,DeweyG
中科院分区：
文献类型：
--
作者：
Schmidt,JohnW;Greenough,Adrienne;Burns,Michelle;Luteran,AndreaE;McCafferty,DeweyG
Ramoplanin is a lipoglycodepsipeptide antimicrobial active against clinically important Gram-positive bacteria including methicillin-resistantStaphylococcus aureus. To proactively examine ramoplanin resistance, we subjectedS. aureusNCTC 8325-4 to serial passage in the presence of increasing concentrations of ramoplanin, generating the markedly resistant strain RRSA16. Susceptibility testing of RRSA16 revealed the unanticipated acquisition of cross-resistance to vancomycin and nisin. RRSA16 displayed phenotypes, including a thickened cell wall and reduced susceptibility to Triton X-100-induced autolysis, which are associated with vancomycin intermediate-resistantS. aureusstrains. Passage of RRSA16 for 18 days in a drug-free medium yielded strain R16-18d with restored antibiotic susceptibility. The RRSA16 isolate may be used to identify the genetic and biochemical basis for ramoplanin resistance and to further our understanding of the evolution of antibiotic cross-resistance mechanisms inS. aureus.
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