Association of biomarkers of systemic inflammation with organic components and source tracers in quasi-ultrafine particles.
Association of biomarkers of systemic inflammation with organic components and source tracers in quasi-ultrafine particles.
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DOI：
10.1289/ehp.0901407
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发表时间：
2010-06
影响因子：
10.4
通讯作者：
Sioutas C
中科院分区：
文献类型：
--
作者：
Delfino RJ;Staimer N;Tjoa T;Arhami M;Polidori A;Gillen DL;Kleinman MT;Schauer JJ;Sioutas C
需要关于空气污染物成分及其来源的证据，这些污染物成分及其来源导致颗粒物质量浓度与人类心血管结果之间的关联。我们此前在对居住在洛杉矶盆地的60名患有冠心病的老年患者进行的小组队列研究中发现，循环中的炎症生物标志物与空气动力学直径中准超细颗粒PM0.25μm的质量浓度之间存在关联。我们使用新的颗粒组成数据重新评估了生物标记物与PM0.25的相关性。每周以血浆白介素6(IL-6)和可溶性肿瘤坏死因子-α受体II(sTNF-RII)作为炎症标志物。暴露于室内和室外社区的有机PM0.25组分[多环芳烃(PAHs)、藿烷、正构烷烃、有机酸、水溶性有机碳和过渡金属]。我们通过对潜在混杂因素进行调整的混合效应模型分析了生物标志物和暴露之间的关系。室内和室外的多环芳烃(低、中、高相对分子质量的多环芳烃)，紧随其后的是并戊烷(机动车尾气示踪剂)，与生物标志物呈正相关，而其他有机成分和过渡金属与生物标志物无关。室外总PAHs每增加0.56 ng/m~3，sTNF-RII增加135 pg/m l[95%可信区间(CI)45~225 pg/m L]，IL-6增加0.27 pg/m l(95%C I，0.10~0.44 pg/m l)。PM0.25和多环芳烃的双污染物模型表明，多环芳烃完全混淆了IL-6和sTNF-RII与PM0.25质量的名义关联。由化学质量平衡模型估算的机动车排放源与多环芳烃有很强的相关性(R=0.71)。以多环芳烃为代表的有机化学品的交通排放源与全身炎症的增加有关，并解释了与准超细颗粒物质量的关联。
Evidence is needed regarding the air pollutant components and their sources responsible for associations between particle mass concentrations and human cardiovascular outcomes. We previously found associations between circulating biomarkers of inflammation and mass concentrations of quasi-ultrafine particles ≤ 0.25 μm in aerodynamic diameter (PM0.25) in a panel cohort study of 60 elderly subjects with coronary artery disease living in the Los Angeles Basin. We reassessed biomarker associations with PM0.25 using new particle composition data. Weekly biomarkers of inflammation were plasma interleukin-6 (IL-6) and soluble tumor necrosis factor-α receptor II (sTNF-RII) (n = 578). Exposures included indoor and outdoor community organic PM0.25 constituents [polycyclic aromatic hydrocarbons (PAHs), hopanes, n-alkanes, organic acids, water-soluble organic carbon, and transition metals]. We analyzed the relation between biomarkers and exposures with mixed-effects models adjusted for potential confounders. Indoor and outdoor PAHs (low-, medium-, and high-molecular-weight PAHs), followed by hopanes (vehicle emissions tracer), were positively associated with biomarkers, but other organic components and transition metals were not. sTNF-RII increased by 135 pg/mL [95% confidence interval (CI), 45–225 pg/mL], and IL-6 increased by 0.27 pg/mL (95% CI, 0.10–0.44 pg/mL) per interquartile range increase of 0.56 ng/m3 outdoor total PAHs. Two-pollutant models of PM0.25 with PAHs showed that nominal associations of IL-6 and sTNF-RII with PM0.25 mass were completely confounded by PAHs. Vehicular emission sources estimated from chemical mass balance models were strongly correlated with PAHs (R = 0.71). Traffic emission sources of organic chemicals represented by PAHs are associated with increased systemic inflammation and explain associations with quasi-ultrafine particle mass.
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超铁颗粒在空气颗粒质量与心血管健康之间关联中的潜在作用。
影响因子：
10.4
作者：
Delfino RJ;Sioutas C;Malik S
通讯作者：
Malik S
DOI：
10.1165/ajrcmb.25.4.4515
发表时间：
2001-10-01
影响因子：
6.4
作者：
Bonvallot, V;Baeza-Squiban, A;Marano, F
通讯作者：
Marano, F
人类受试者的个人暴露于亚微米颗粒和心率变异性。
影响因子：
10.4
作者：
Chan, Chang-Chuan;Chuang, Kai-Jen;Shiao, Guang-Ming;Lin, Lian-Yu
通讯作者：
Lin, Lian-Yu
影响因子：
20.1
作者：
Araujo, Jesus A.;Barajas, Berenice;Nel, Andre E.
通讯作者：
Nel, Andre E.
影响因子：
10.4
作者：
Delfino, Ralph J.;Staimer, Norbert;Sioutas, Constantinos
通讯作者：
Sioutas, Constantinos