Biosynthesis of S-adenosyl-methionine enhances aging-related defects in Drosophila oogenesis.
Biosynthesis of S-adenosyl-methionine enhances aging-related defects in Drosophila oogenesis.
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DOI：
10.1038/s41598-022-09424-1
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发表时间：
2022-04-04
影响因子：
4.6
通讯作者：
Namihira M
中科院分区：
文献类型：
--
作者：
Hayashi Y;Kashio S;Murotomi K;Hino S;Kang W;Miyado K;Nakao M;Miura M;Kobayashi S;Namihira M
组织老化是衰老相关残疾和寿命缩短的主要原因。了解组织老化的过程和确定组织老化的潜在因素至关重要；然而，组织老化的机制尚不完全清楚。在这里，我们发现s -腺苷-蛋氨酸（SAM）的生物合成是甲基化修饰的主要细胞供体，可以有效地加速果蝇卵子发生过程中与衰老相关的缺陷。生殖系SAM-合成酶（SAM-s）水平的衰老相关增加导致卵巢SAM水平的增加。SAM - s依赖性的生物合成通过两种机制控制卵子发生中与衰老相关的缺陷，降低维持种系干细胞的能力，加速卵室的不当形成。衰老相关的SAM增加通常发生在小鼠生殖组织和大脑中。因此，我们的研究结果提出了SAM是超越物种和组织的组织衰老相关因素的可能性。
Tissue aging is a major cause of aging-related disabilities and a shortened life span. Understanding how tissue aging progresses and identifying the factors underlying tissue aging are crucial; however, the mechanism of tissue aging is not fully understood. Here we show that the biosynthesis of S-adenosyl-methionine (SAM), the major cellular donor of methyl group for methylation modifications, potently accelerates the aging-related defects during Drosophila oogenesis. An aging-related increase in the SAM-synthetase (Sam-S) levels in the germline leads to an increase in ovarian SAM levels. Sam-S-dependent biosynthesis of SAM controls aging-related defects in oogenesis through two mechanisms, decreasing the ability to maintain germline stem cells and accelerating the improper formation of egg chambers. Aging-related increases in SAM commonly occur in mouse reproductive tissue and the brain. Therefore, our results raise the possibility suggesting that SAM is the factor related to tissue aging beyond the species and tissues.
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影响因子：
5.8
作者：
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通讯作者：
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作者：
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通讯作者：
Bennett, David A.
影响因子：
4.5
作者：
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