Effect of CYP2C9 genetic polymorphism on the metabolism of flurbiprofen in vitro

Effect of CYP2C9 genetic polymorphism on the metabolism of flurbiprofen in vitro
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CYP2C9基因多态性对氟比洛芬体外代谢的影响

DOI:
10.3109/03639045.2014.950274
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发表时间:
2015-07
影响因子:
3.4
通讯作者:
Hu Guo-Xin
Hu Guo-Xin
中科院分区:
医学4区
文献类型:
--
作者:
Wang Li;Bao Shi-Hui;Pan Pei-Pei;Xia Meng-Ming;Chen Meng-Chun;Liang Bing-Qing;Dai Da-Peng;Cai Jian-Ping;Hu Guo-Xin

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CYP2C9是细胞色素P450酶超家族的重要成员,已有57个细胞色素P450 2C9等位基因被报道。为了检测CYP2C9等位基因的酶活性,采用了4′-羟基氟比洛芬的动力学参数
Abstract CYP2C9 is an important member of the cytochrome P450 enzyme superfamily, and 57 cytochrome P450 2C9 alleles have been previously reported. To examine the enzymatic activity of the CYP2C9 alleles, kinetic parameters for 4′-hydroxyflurbiprofen were
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