Enhanced motor learning following task-concurrent dual transcranial direct current stimulation.
Enhanced motor learning following task-concurrent dual transcranial direct current stimulation.
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DOI：
10.1371/journal.pone.0085693
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Witney AG
中科院分区：
文献类型：
--
作者：
Karok S;Witney AG
初级运动皮层 (M1) 的经颅直流电刺激 (tDCS) 对健康受试者的运动表现和运动学习具有有益影响，并且正在成为运动神经康复的一种有前途的工具。最近发现，与运动任务同时应用 tDCS 比在运动任务之前应用刺激更有效。这项研究扩展了这一发现，以检验这种任务并发刺激是否进一步增强了双 M1 蒙太奇的运动学习。 20 名健康的右手受试者在重复测量设计中接受了右侧 M1 的阳极 tDCS、双 tDCS（右侧 M1 上的阳极电流和左侧 M1 上的阴极电流）和假 tDCS。在显性运动学习任务期间，以 1.5 mA 电流施加刺激 10 分钟。在基线、刺激期间、刺激后立即和刺激后 15 分钟测量响应时间 (RT) 和准确性。使用单脉冲经颅磁刺激刺激之前和之后记录两个半球的运动皮质兴奋性。 早在刺激开始时，双 M1 蒙太奇的任务并发刺激就显着降低了 23% 的 RT（p<0.01），这种效应在最终测量时增加到 30%。观察到皮质兴奋性的极性特异性变化，左侧 M1 中的 MEP 显着减少 12%，右侧 M1 中增加 69%。 双M1条件下性能改善最早出现，效果稳定持久。与假手术相比，单侧阳极刺激仅导致趋势改善。因此，任务并发双 M1 刺激最适合在显性运动学习中获得 tDCS 所需的神经调节效果。
Transcranial direct current stimulation (tDCS) of the primary motor cortex (M1) has beneficial effects on motor performance and motor learning in healthy subjects and is emerging as a promising tool for motor neurorehabilitation. Applying tDCS concurrently with a motor task has recently been found to be more effective than applying stimulation before the motor task. This study extends this finding to examine whether such task-concurrent stimulation further enhances motor learning on a dual M1 montage. Twenty healthy, right-handed subjects received anodal tDCS to the right M1, dual tDCS (anodal current over right M1 and cathodal over left M1) and sham tDCS in a repeated-measures design. Stimulation was applied for 10 mins at 1.5 mA during an explicit motor learning task. Response times (RT) and accuracy were measured at baseline, during, directly after and 15 mins after stimulation. Motor cortical excitability was recorded from both hemispheres before and after stimulation using single-pulse transcranial magnetic stimulation. Task-concurrent stimulation with a dual M1 montage significantly reduced RTs by 23% as early as with the onset of stimulation (p<0.01) with this effect increasing to 30% at the final measurement. Polarity-specific changes in cortical excitability were observed with MEPs significantly reduced by 12% in the left M1 and increased by 69% in the right M1. Performance improvement occurred earliest in the dual M1 condition with a stable and lasting effect. Unilateral anodal stimulation resulted only in trendwise improvement when compared to sham. Therefore, task-concurrent dual M1 stimulation is most suited for obtaining the desired neuromodulatory effects of tDCS in explicit motor learning.
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