Blocking the Interaction between EphB2 and ADDLs by a Small Peptide Rescues Impaired Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer's Disease

Blocking the Interaction between EphB2 and ADDLs by a Small Peptide Rescues Impaired Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer's Disease
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通过小肽阻断 EphB2 和 ADDL 之间的相互作用可挽救阿尔茨海默病小鼠模型中受损的突触可塑性和记忆缺陷

DOI:
10.1523/jneurosci.1327-16.2016
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发表时间:
2016-11
影响因子:
5.3
通讯作者:
Gao Can
Gao Can
中科院分区:
医学1区
文献类型:
--
作者:
Shi Xiao-Dong;Sun Kai;Hu Rui;Liu Xiao-Ya;Hu Qiu-Mei;Sun Xiao-Yu;Yao Bin;Sun Nan;Hao Jing-Ru;Wei Pan;Han Yuan;Gao Can

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Soluble amyloid-β (Aβ) oligomers, also known as Aβ-derived diffusible ligands (ADDLs), are thought to be the key pathogenic factor in Alzheimer's disease (AD), but there is still no effective treatment for preventing or reversing the progression of the di
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