Neuronal Membrane D2‐Protein During Rat Brain Ontogeny
Neuronal Membrane D2‐Protein During Rat Brain Ontogeny
复制标题
大鼠脑个体发育过程中的神经元膜 D2-蛋白
DOI：
10.1111/j.1471-4159.1981.tb04481.x
复制
发表时间：
1981
影响因子：
4.7
通讯作者：
O. Jørgensen
中科院分区：
文献类型：
--
作者：
O. Jørgensen
摘要D2蛋白在胎儿和围产期大鼠脑中以唾液酸化形式存在，在成年大鼠脑中以去唾液酸化形式存在。通过交叉免疫电泳，研究了前脑和小脑个体发育过程中这些形式的浓度和数量。唾液酸化D2-蛋白的浓度在个体发育期间达到两个峰值。第一个高峰出现在胚胎第13天左右的前脑，出生后的小脑。在这两个大脑区域，它与主要神经元迁移的时期相吻合。第二个高峰出现在出生后6天左右的前脑和出生后20天左右的小脑，在两个脑区的突触发生的初始阶段。此外，仅在出生后大鼠中发现去唾液酸化形式的D2-蛋白，并且在出生后第25天在前脑中和出生后第35天在小脑中增加至最大值。研究结果进行了讨论有关D2蛋白作为粘附分子的可能作用。
Abstract The D2‐protein exists as a sialylated form in fetal and in perinatal rat brain, and as a desialylated form in adult rat brain. By crossed Immunoelectrophoresis the concentrations and amounts of these forms were investigated during ontogeny of both forebrain and cerebellum. The concentration of sialylated D2‐protein reached two peaks during ontogeny. The first peak occurred in forebrain around embryonic day 13, and in cerebellum just after birth. In both brain areas it coincided with the periods of major neuronal migration. The second peak occurred in forebrain around postnatal day 6 and in cerebellum around postnatal day 20, during the initial period of synaptogenesis in both brain areas. Moreover, the desialylated form of D2‐protein was found only in postnatal rats and it increased to a slight maximum at postnatal day 25 in forebrain, and postnatal day 35 in cerebellum. The findings are discussed in relation to the possible role of D2‐protein as an adhesion molecule.
在胚胎发生过程中，视神经纤维的生长会跟随邻近的纤维生长。
DOI：
10.1073/pnas.77.7.4374
发表时间：
1980
影响因子：
11.1
作者：
Bodick,N;Levinthal,C
通讯作者：
Levinthal,C