The applications of buckminsterfullerene C60 and derivatives in orthopaedic research.
The applications of buckminsterfullerene C60 and derivatives in orthopaedic research.
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DOI：
10.3109/03008207.2013.877894
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发表时间：
2014-04
影响因子：
2.9
通讯作者：
Jin L
中科院分区：
文献类型：
--
作者：
Liu Q;Cui Q;Li XJ;Jin L
巴克敏斯特富勒烯C60及其衍生物由于其独特的结构和无可比拟的物理化学性质，在生物医学研究中得到了广泛的探索。C60的特点是“自由基海绵”，其抗氧化功效比传统抗氧化剂高出数百倍。此外，C60核心具有很强的电子吸引能力，许多具有不同性质的功能化合物可以添加到这个富勒烯笼中。本文综述了C60及其衍生物在骨科研究中的应用，如软骨退变、骨破坏、椎间盘退变、椎体骨髓疾病、神经根病等的治疗，以及它们在体外和体内的毒性。我们认为，C60及其衍生物，特别是具有新的生物和药理活性的C60核心，在骨科研究中具有优势，在肌肉骨骼疾病的临床治疗中具有广阔的应用前景；然而，这些药物作为局部/全身给药的药代动力学和毒理学需要仔细确定。
Buckminsterfullerene C60 and derivatives have been extensively explored in biomedical research due to their unique structure and unparalleled physicochemical properties. C60 is characterized as a “free radical sponge” with an anti-oxidant efficacy several hundred-fold higher than conventional anti-oxidants. Also, the C60 core has a strong electron-attracting ability and numerous functional compounds with widely different properties can be added to this fullerene cage. This review focused on the applications of C60 and derivatives in orthopaedic research, such as the treatment of cartilage degeneration, bone destruction, intervertebral disc degeneration (IVDD), vertebral bone marrow disorder, radiculopathy, etc., as well as their toxicity in vitro and in vivo. We suggest that C60 and derivatives, especially the C60 cores coupled with functional groups presenting new biological and pharmacological activities, are advantageous in orthopaedic research and will be promising in clinical performance for musculoskeletal disorders treatment; however, the pharmacokinetics and toxicology of these agents as local/systemic administration need to be carefully determined.
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影响因子：
4.5
作者：
Cui, Min;Wan, Yuqing;Li, Xudong
通讯作者：
Li, Xudong
DOI：
10.1196/annals.1397.069
发表时间：
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期刊：
SIGNAL TRANSDUCTION PATHWAYS, PT D
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影响因子：
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作者：
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影响因子：
3
作者：
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通讯作者：
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