Cell-to-cell signalling during pathogenesis.
Cell-to-cell signalling during pathogenesis.
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DOI：
10.1111/j.1462-5822.2008.01272.x
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发表时间：
2009-03
影响因子：
3.4
通讯作者：
Sperandio V
中科院分区：
文献类型：
--
作者：
Parker CT;Sperandio V
致病菌只有在感觉到它们处于致病所需能量有保证的位置时才产生毒力因子。由病原体监测的一个环境因素是种群密度，其自身种群或宿主内源性植物群的种群密度。到目前为止，已经描述了四种系统，它们允许病原体以种群依赖的方式调节毒力基因。这些系统存在于革兰氏阳性和革兰氏阴性细胞中，并利用各种机制在转录水平上控制基因调控，但它们都具有一个共同的特征：它们检测由属于病原体群体或宿主植物群的细胞释放的自诱导物。本文探讨了这四个信号系统在细菌群落中的作用，以及病原体如何利用这些系统来控制宿主入侵和感染过程中所需的基因。
Pathogenic bacteria produce virulence factors only when they sense they are in a location in which the energy required for pathogenesis is warranted. One environmental factor monitored by pathogens is population density, either of its own population or of the population of a host’s endogenous flora. To date, four systems have been described which allow pathogens to regulate virulence genes in a population-dependent manner. These systems are found in both Gram-positive and Gram-negative cells and utilize various mechanisms to control gene regulation at a transcriptional level, but they all have one feature in common: they detect auto-inducers released by cells belonging to either the pathogen’s population or that of the host’s flora. This article explores the role of these four signalling systems in bacterial communities and how pathogens use these systems to control genes required during host invasion and infection.
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影响因子：
3.6
作者：
Kanamaru, K;Kanamaru, K;Sasakawa, C
通讯作者：
Sasakawa, C
影响因子：
2.8
作者：
Coulthurst, Sarah J.;Williamson, Neil R.;Salmond, George P. C.
通讯作者：
Salmond, George P. C.
影响因子：
16
作者：
Miller, ST;Xavier, KB;Hughson, FM
通讯作者：
Hughson, FM
影响因子：
3.2
作者：
Sperandio, V;Torres, AG;Kaper, JB
通讯作者：
Kaper, JB
DOI：
10.1073/pnas.93.18.9505
发表时间：
1996-09-03
影响因子：
11.1
作者：
Schaefer, AL;Val, DL;Greenberg, EP
通讯作者：
Greenberg, EP