Mushroom body input connections form independently of sensory activity in Drosophila melanogaster.
Mushroom body input connections form independently of sensory activity in Drosophila melanogaster.
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DOI：
10.1016/j.cub.2022.07.055
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发表时间：
2022-09-26
期刊：
影响因子：
9.2
通讯作者：
Caron, Sophie Jeanne Cecille
中科院分区：
文献类型：
--
作者：
Hayashi, Tatsuya Tatz;MacKenzie, Alexander John;Ganguly, Ishani;Ellis, Kaitlyn Elizabeth;Smihula, Hayley Marie;Jacob, Miles Solomon;Litwin -Kumar, Ashok;Caron, Sophie Jeanne Cecille
联合脑中心，如昆虫蘑菇体，需要以有效的方式表示感觉信息。在果蝇中，蘑菇体的Kenyon细胞整合了一组随机的嗅觉投射神经元的输入，但一些投射神经元--即那些被一些有行为学意义的气味激活的投射神经元--比其他神经元更频繁地连接到Kenyon细胞。这种偏向和随机的连接模式是可以想象的有利的，因为它使蘑菇体能够将大量气味表示为独特的活动模式，同时优先表示几种特定气味。这种连接模式是如何建立的，目前在很大程度上尚不清楚。在这里，我们测试凯尼恩细胞和投射神经元之间连接的机制是否依赖于感觉活动，或者它们是否是硬连接的。我们在部分无嗅觉苍蝇-缺乏专有气味共同受体Orco的苍蝇-和野生型苍蝇中绘制了大量蘑菇体输入连接的图谱。对这些数据集的统计分析表明，在没有大多数嗅觉活动的情况下，观察到的Kenyon细胞和投射神经元之间的随机和有偏见的连接模式正常形成。这一发现支持这样一种观点，即即使是相对微妙的、种群水平的神经元连接模式也可以由固定的遗传程序编码，很可能是对生态和行为学上突出的刺激进行进化优先排序的结果。
Associative brain centers, such as the insect mushroom body, need to represent sensory information in an efficient manner. In Drosophila melanogaster, the Kenyon cells of the mushroom body integrate inputs from a random set of olfactory projection neurons, but some projection neurons — namely those activated by a few ethologically meaningful odors — connect to Kenyon cells more frequently than others. This biased and random connectivity pattern is conceivably advantageous, as it enables the mushroom body to represent a large number of odors as unique activity patterns while prioritizing the representation of a few specific odors. How this connectivity pattern is established remains largely unknown. Here, we test whether the mechanisms patterning the connections between Kenyon cells and projection neurons depend on sensory activity or whether they are hardwired. We mapped a large number of mushroom body input connections in partially anosmic flies — flies lacking the obligate odorant co-receptor Orco — and in wildtype flies. Statistical analyses of these datasets reveal that the random and biased connectivity pattern observed between Kenyon cells and projection neurons forms normally in the absence of most olfactory sensory activity. This finding supports the idea that even comparatively subtle, population-level patterns of neuronal connectivity can be encoded by fixed genetic programs and are likely to be the result of evolved prioritization of ecologically and ethologically salient stimuli.
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影响因子：
9.8
作者：
Ebrahim SA;Dweck HK;Stökl J;Hofferberth JE;Trona F;Weniger K;Rybak J;Seki Y;Stensmyr MC;Sachse S;Hansson BS;Knaden M
通讯作者：
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16.2
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通讯作者：
Rubin GM
影响因子：
9.8
作者：
Benton, Richard;Sachse, Silke;Michnick, Stephen W;Vosshall, Leslie B
通讯作者：
Vosshall, Leslie B
DOI：
10.1523/jneurosci.5984-10.2011
发表时间：
2011-05-25
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kazama H;Yaksi E;Wilson RI
通讯作者：
Wilson RI