Thermonociceptive interaction: interchannel pain modulation occurs before intrachannel convergence of warmth.
Thermonociceptive interaction: interchannel pain modulation occurs before intrachannel convergence of warmth.
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热痛感受相互作用：通道间疼痛调节发生在通道内温暖收敛之前。
DOI：
10.1152/jn.00341.2018
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发表时间：
2019
影响因子：
2.5
通讯作者：
Cataldo A
中科院分区：
文献类型：
--
作者：
Cataldo A
无害的温暖降低了感知的疼痛强度和疼痛的EEG标记的幅度。然而，空间特性的热感相互作用，并在其发生的感觉处理的水平，仍然不清楚。我们研究了通道间的温暖-疼痛相互作用是否发生在通道内空间温暖总和之前或之后。对右手的手指施加热刺激。它们的数量和位置在不同的条件下被操纵。使用CO2激光器将伴随的有害测试脉冲传递到中指。我们复制了经典的抑制作用的温暖感知疼痛强度和脑电图标记。重要的是，疼痛抑制不受热刺激的位置和数量的影响，即使它们增加了感知的温暖强度。因此，我们的研究结果表明，温暖对疼痛的抑制作用是没有躯体组织。结果还排除了可能性，温暖影响伤害性处理后，通道内的温暖summation.NEW & NOTEWORTHYWe空间求和的温暖作为一个模型来调查thermociceptive的相互作用。在不同的热条件下输送疼痛的CO2激光脉冲。我们发现，温暖抑制疼痛，不管它的位置。重要的是，多个温暖刺激的空间总和并没有进一步抑制疼痛。这些研究结果表明，温暖疼痛的相互作用发生独立的空间或温暖的总和后。
Nonnoxious warmth reduces both perceived pain intensity and the amplitude of EEG markers of pain. However, the spatial properties of thermonociceptive interaction, and the level of sensory processing at which it occurs, remain unclear. We investigated whether interchannel warmth-pain interactions occur before or after intrachannel spatial summation of warmth. Warm stimuli were applied to the fingers of the right hand. Their number and location were manipulated in different conditions. A concomitant noxious test pulse was delivered to the middle finger using a CO2laser. We replicated the classical suppressive effect of warmth on both perceived pain intensity and EEG markers. Importantly, inhibition of pain was not affected by the location and the number of thermal stimuli, even though they increased the perceived intensity of warmth. Our results therefore suggest that the inhibitory effect of warmth on pain is not somatotopically organized. The results also rule out the possibility that warmth affects nociceptive processing after intrachannel warmth summation.NEW & NOTEWORTHYWe used spatial summation of warmth as a model to investigate thermonociceptive interactions. Painful CO2laser pulses were delivered during different thermal conditions. We found that warmth inhibited pain regardless of its location. Crucially, spatial summation of multiple warm stimuli did not further inhibit pain. These findings suggest that warmth-pain interaction occurs independently of or after spatial summation of warmth.
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使用温控红外激光刺激器结合自适应阶梯算法，对 C 纤维传入的选择性激活进行可靠的 EEG 响应
影响因子：
7.4
作者：
A. Jankovski;L. Plaghki;A. Mouraux
通讯作者：
A. Mouraux
热痛的空间总和：重新评估
影响因子：
7.4
作者：
R. Defrin;G. Urca
通讯作者：
G. Urca
DOI：
10.1007/978-94-010-2245-3_36
发表时间：
1974
期刊：
The Journal of rheumatology
影响因子：
--
作者：
L. Marks
通讯作者：
L. Marks
影响因子：
2.9
作者：
MARCHAND, S;BUSHNELL, MC;DUNCAN, GH
通讯作者：
DUNCAN, GH
影响因子：
5.3
作者：
Ho, Hsin-Ni;Watanabe, Junji;Kashino, Makio
通讯作者：
Kashino, Makio