Improvement of hemolytic anemia with GBT1118 is renoprotective in transgenic sickle mice.

Improvement of hemolytic anemia with GBT1118 is renoprotective in transgenic sickle mice.
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DOI:
10.1182/bloodadvances.2022007809
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发表时间:
2022-08-09
期刊:
影响因子:
7.5
通讯作者:
Saraf, Santosh L.
Saraf, Santosh L.
中科院分区:
医学1区
文献类型:
--
作者:
Ren, Guohui;Setty, Suman;Zhang, Xu;Susma, Alexandru;Ruiz, Maria Armila;Minshall, Richard D.;Lash, James P.;Gordeuk, Victor R.;Saraf, Santosh L.

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在转基因镰状小鼠中,用voxelotor类似物GBT 1118减少溶血,减少血红蛋白尿和肾损伤生物标志物。改善慢性溶血保护肾功能和组织病理学和超微结构的变化,在转基因镰刀小鼠。
A reduction in hemolysis with voxelotor analog, GBT1118, reduced hemoglobinuria and kidney injury biomarkers in transgenic sickle mice. Improved chronic hemolysis preserved kidney function and histopathologic and ultrastructural changes in transgenic sickle mice.
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