From pumps to prevention: recent advances in the treatment of type 1 diabetes.

From pumps to prevention: recent advances in the treatment of type 1 diabetes.
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从泵到预防:1 型糖尿病治疗的最新进展。

DOI:
10.1016/j.drudis.2009.06.011
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发表时间:
2009
影响因子:
7.4
通讯作者:
W. Tamborlane
W. Tamborlane
中科院分区:
医学2区
文献类型:
--
作者:
J. Sherr;E. Cengiz;W. Tamborlane

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在过去的30年里,1型糖尿病(T1DM)儿科患者的治疗选择发生了巨大变化。包括持续皮下胰岛素输注(CSII)和持续葡萄糖监测(CGM)开发在内的技术进步已允许改善胰岛素输注并更好地了解血糖波动。CSII和CGM的操作将允许人工胰腺的发展,这项技术的初步研究将进行审查。已经开发了治疗T1DM的新药物,例如速效胰岛素。另一个探索领域是导致β细胞破坏的自身免疫过程。将对用于T1DM预防和二级干预的免疫调节剂进行综述。
Treatment options for pediatric patients living with type 1 diabetes mellitus (T1DM) have drastically changed over the past 30 years. Technological advances including the development of continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring (CGM) have allowed for improved insulin delivery and a better understanding of blood glucose fluctuations. Manipulations of CSII and CGM will allow for the development of an artificial pancreas; initial studies of this technology will be reviewed. New medications for the treatment of T1DM have been developed, such as rapid-acting insulins. Another area of exploration is the autoimmune process that causes β-cell destruction. Immunomodulators used for T1DM prevention and secondary intervention will be reviewed.
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