Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy.
Metabolic Switch in the Tumor Microenvironment Determines Immune Responses to Anti-cancer Therapy.
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DOI：
10.3389/fonc.2018.00284
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发表时间：
2018
影响因子：
4.7
通讯作者：
Seth P
中科院分区：
文献类型：
--
作者：
Wegiel B;Vuerich M;Daneshmandi S;Seth P
肿瘤诱导的免疫耐受允许恶性细胞的生长和扩散。癌细胞对周围细胞有很强的影响，并形成促进癌症进展的缺氧肿瘤微环境（TME）。癌细胞中发生的葡萄糖代谢的动态变化及其对TME的影响仍然知之甚少。事实上，癌症和/或免疫细胞在癌症进展期间经历代谢途径的快速适应。代谢重编程影响巨噬细胞、T细胞和髓源性抑制细胞（MDSC）以及其他免疫细胞。它们在TME中的作用取决于因子的性质和浓度，所述因子例如细胞因子、活性氧（ROS）、生长因子，以及最重要的是可扩散代谢物（即，乳酸盐）。此外，可用营养物和氧气的量以及微生物群的活性可能影响TME中的代谢途径。本文就代谢物在调节免疫与癌细胞相互作用中的作用作一综述。靶向TME中控制细胞代谢的代谢重编程或信号通路可能是单独或与当前免疫疗法组合的抗癌疗法的潜在策略。
Tumor-induced immune tolerance permits growth and spread of malignant cells. Cancer cells have strong influence on surrounding cells and shape the hypoxic tumor microenvironment (TME) facilitating cancer progression. A dynamic change in glucose metabolism occurring in cancer cells and its influence on the TME are still poorly understood. Indeed, cancer and/or immune cells undergo rapid adaptation in metabolic pathways during cancer progression. Metabolic reprograming affects macrophages, T cells, and myeloid derived suppressor cells (MDSCs) among other immune cells. Their role in the TME depends on a nature and concentration of factors, such as cytokines, reactive oxygen species (ROS), growth factors, and most importantly, diffusible metabolites (i.e., lactate). Further, the amounts of available nutrients and oxygen as well as activity of microbiota may influence metabolic pathways in the TME. The roles of metabolites in regulating of the interaction between immune and cancer cell are highlighted in this review. Targeting metabolic reprogramming or signaling pathways controlling cell metabolism in the TME might be a potential strategy for anti-cancer therapy alone or in combination with current immunotherapies.
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影响因子：
30.5
作者：
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通讯作者：
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