The role and therapeutic potential of endothelial progenitor cells in tumor neovascularization.
The role and therapeutic potential of endothelial progenitor cells in tumor neovascularization.
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DOI：
10.1100/tsw.2010.100
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发表时间：
2010-06-15
影响因子：
--
通讯作者：
Arbab AS
中科院分区：
文献类型：
--
作者：
Janic B;Arbab AS
虽然肿瘤生长和转移的细胞和分子机制尚未完全了解，但已确定新血管的形成和生长是肿瘤存活、生长和扩张的必要条件。过去几十年的许多研究表明，与肿瘤生长相关的新血管形成是通过血管生成和血管生成机制发生的，这些机制涉及萌芽性血管生成、套叠性血管生成、血管共选择、血管生成拟态、淋巴管生成和内皮祖细胞的募集（EPCs）。由于其自我更新、循环、归巢缺血部位和分化成成熟内皮细胞的能力，EPC在抗肿瘤疗法中具有用作诊断和/或治疗剂的巨大潜力。因此，这篇综述的重点是内皮祖细胞及其在肿瘤血管生成中的作用，重点是内皮祖细胞的招募/迁移，以及内皮祖细胞作为治疗工具和成像探针的潜在用途。
Although the cellular and molecular mechanisms of tumor growth and metastasis are not completely understood, it is established that formation and growth of new blood vessels is a conditio sine qua non for tumor survival, growth, and expansion. Numerous studies over the past decades demonstrated that neovascularization associated with tumor growth occurs via angiogenic and vasculogenic mechanisms that involve sprouting angiogenesis, intussusceptive angiogenesis, vessel co-option, vasculogenic mimicry, lymphangiogenesis, and the recruitment of endothelial progenitor cells (EPCs). Due to their ability to self-renew, circulate, home to the ischemic sites, and differentiate into mature endothelial cells, EPCs hold enormous potential to be used as a diagnostic and/or therapeutic agent in antitumor therapies. Hence, this review focuses on EPCs and their role in tumor angiogenesis with the emphasis on EPC recruitment/migration, and the potential use of EPCs as a therapeutic tool and imaging probe.
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影响因子：
56.9
作者：
Asahara, T;Murohara, T;Isner, JM
通讯作者：
Isner, JM
影响因子：
11.2
作者：
Dome, Balazs;Timar, Jozsef;Tovari, Jozsef
通讯作者：
Tovari, Jozsef
DOI：
10.1007/bf01476669
发表时间：
1978-01-01
期刊：
KLINISCHE WOCHENSCHRIFT
影响因子：
--
作者：
HLADOVEC, J;PREROVSKY, I;FABIAN, J
通讯作者：
FABIAN, J
影响因子：
82.9
作者：
Ceradini, DJ;Kulkarni, AR;Gurtner, GC
通讯作者：
Gurtner, GC
通过预防新血管形成，体内肿瘤休眠。
影响因子：
15.3
作者：
Gimbrone, M A Jr;Leapman, S B;Cotran, R S;Folkman, J
通讯作者：
Folkman, J