Phylogenetic clustering of hepatitis C virus among people who inject drugs in Vancouver, Canada.
Phylogenetic clustering of hepatitis C virus among people who inject drugs in Vancouver, Canada.
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加拿大温哥华注射吸毒者中丙型肝炎病毒的系统发育聚类。
DOI：
10.1002/hep.27310
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发表时间：
2014-11
期刊：
影响因子：
13.5
通讯作者：
Grebely, Jason
中科院分区：
文献类型：
--
作者：
Jacka, Brendan;Applegate, Tanya;Krajden, Mel;Olmstead, Andrea;Harrigan, P. Richard;Marshall, Brandon D. L.;DeBeck, Kora;Milloy, M. -J.;Lamoury, Francois;Pybus, Oliver G.;Lima, Viviane D.;Magiorkinis, Gkikas;Montoya, Vincent;Montaner, Julio;Joy, Jeffrey;Woods, Conan;Dobrer, Sabina;Dore, Gregory J.;Poon, Art F. Y.;Grebely, Jason
关于注射毒品者（PWID）中HCV传播相关因素知之甚少。在加拿大温哥华的PWID中评估系统发生聚类和相关因素。数据来自温哥华注射吸毒者研究。对入组时HCV抗体阳性的参与者和随访期间（1996年至2012年）HCV抗体血清转换的参与者进行HCV RNA检测和测序（Core-E2区域）。使用最大似然分析推断系统发育树，并使用QuestionPicker（90%自举阈值，0.05遗传距离阈值）鉴定聚类。与聚类相关的因素进行了评估，使用逻辑回归。在655名符合条件的参与者中，HCV基因型患病率为：G1 a：48%（n=313），G1 b：6%（n=41），G2 a：3%（n=20），G2 b：7%（n=46），G3 a：33%（n=213），G4 a：<1%（n=4），G6 a：1%（n=8），G6 e：<1%（n=1）和无法分类：1%（n=9）。平均年龄为36岁，162例（25%）为女性，164例（25%）为HIV阳性。在501名HCV G1 a和G3 a参与者中，31%（n=156）在一对/集群中。与系统发育聚类独立相关的因素包括：年龄<40岁（与年龄≥40岁相比，调整的比值比[AOR] = 1.64; 95% CI 1.03，2.63），HIV感染（AOR = 1.82; 95% CI 1.18，2.81）、HCV血清转换（AOR = 3.05; 95% CI 1.40，6.66）和近期注射器借用（AOR 1.59; 95% CI 1.07，2.36）。在这个PWID样本中，三分之一表现出系统发育聚类。与系统发生聚类独立相关的因素包括年龄较小、近期HCV血清转换、流行的HIV感染和近期注射器借用。鉴于HCV在这些亚群中传播的可能性增加，应探讨加强对HIV感染者和近期HCV血清转化者提供预防和/或治疗策略的策略。
Little is known about factors associated with HCV transmission among people who inject drugs (PWID). Phylogenetic clustering and associated factors were evaluated among PWID in Vancouver, Canada. Data were derived from the Vancouver Injection Drug Users Study. Participants who were HCV antibody positive at enrolment and those with HCV antibody seroconversion during follow-up (1996 to 2012) were tested for HCV RNA and sequenced (Core-E2 region). Phylogenetic trees were inferred using maximum likelihood analysis and clusters were identified using ClusterPicker (90% bootstrap threshold, 0.05 genetic distance threshold). Factors associated with clustering were assessed using logistic regression. Among 655 eligible participants, HCV genotype prevalence was: G1a: 48% (n=313), G1b: 6% (n=41), G2a: 3% (n=20), G2b: 7% (n=46), G3a: 33% (n=213), G4a: <1% (n=4), G6a: 1% (n=8), G6e: <1% (n=1) and unclassifiable: 1% (n=9). The mean age was 36 years, 162 (25%) were female and 164 (25%) were HIV+. Among 501 participants with HCV G1a and G3a, 31% (n=156) were in a pair/cluster. Factors independently associated with phylogenetic clustering included: age <40 (vs. age ≥40, adjusted odds ratio [AOR] = 1.64; 95% CI 1.03, 2.63), HIV infection (AOR = 1.82; 95% CI 1.18, 2.81), HCV seroconversion (AOR = 3.05; 95% CI 1.40, 6.66) and recent syringe borrowing (AOR 1.59; 95% CI 1.07, 2.36). In this sample of PWID, one-third demonstrated phylogenetic clustering. Factors independently associated with phylogenetic clustering included younger age, recent HCV seroconversion, prevalent HIV infection, and recent syringe borrowing. Strategies to enhance the delivery of prevention and/or treatment strategies to those with HIV and recent HCV seroconversion should be explored, given an increased likelihood of HCV transmission in these sub-populations.
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影响因子：
6
作者：
Bruneau, Julie;Roy, Elise;Jutras-Aswad, Didier
通讯作者：
Jutras-Aswad, Didier
影响因子：
5.8
作者：
Kuiken, C;Yusim, K;Richardson, R
通讯作者：
Richardson, R
DOI：
10.1111/j.1440-1746.2007.05032.x
发表时间：
2007-09-01
影响因子：
4.1
作者：
Grebely, Jason;Raffa, Jesse D.;Conway, Brian
通讯作者：
Conway, Brian
影响因子：
5.8
作者：
Larkin, M. A.;Blackshields, G.;Higgins, D. G.
通讯作者：
Higgins, D. G.
影响因子：
13.5
作者：
Miller, CL;Johnston, C;Schechter, MT
通讯作者：
Schechter, MT