Acupuncture modulates the frequency-specific functional connectivity density in primary dysmenorrhea.
Acupuncture modulates the frequency-specific functional connectivity density in primary dysmenorrhea.
复制标题
针刺调节原发性痛经的频率特异性功能连接密度。
DOI：
10.3389/fnins.2022.917721
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发表时间：
2022
影响因子：
4.3
通讯作者：
Yang, Jie
中科院分区：
文献类型：
--
作者：
Liu, Li-Ying;Li, Xiang;Tian, Zi-Lei;Zhang, Qi;Shen, Zhi-Fu;Wei, Wei;Guo, Xiao-Li;Chen, Ling;Su, Meng-Hua;Yang, Lu;Yu, Si-Yi;Yang, Jie
该研究旨在研究针灸如何在多个频带上调节大脑活动，以达到PDM的治疗效果。将47例PDM患者随机分为真针组和假针组，针刺3个月经周期。在基线和三个周期治疗后评估fMRI扫描、视觉模拟量表（VAS）评分和其他临床评价。在全低频带、Slow-3带、Slow-4带、Slow-5带对两组患者针刺前后的脑功能连接密度（gFCD）进行分析。经针刺治疗后，腹针组PDM患者VAS评分明显降低（p < 0.05）。结果表明，针刺组大鼠的gFCD呈频率依赖性变化，主要改变区域包括DLPFC、体感皮层、前扣带皮层（ACC）、中扣带皮层（MCC）、楔前叶、海马和小脑皮层。假针刺调制的区域包括角回、额下回和海马。腹针治疗后PDM患者DLPFC Slow-5频段gFCD变化呈负相关，Slow-4频段S2变化与VAS评分呈正相关。这些结果支持了真针可以通过影响Slow-5频段的异常DLPFC和Slow-3频段的海马来有效调节PDM的频率依赖性gFCD。本研究结果对提高针灸的临床效能有一定的参考价值。
The study aimed to investigate how acupuncture modulates brain activities across multiple frequency bands to achieve therapeutic effects in PDM. A total of 47 patients with PDM were randomly assigned to the verum acupuncture group and sham acupuncture group with three menstrual cycles of the acupuncture course. The fMRI scans, visual analog scale (VAS) scores, and other clinical evaluations were assessed at baseline and after three menstrual-cycles treatments. The global functional connectivity density (gFCD) analyses were performed between the pre-and post-acupuncture course of two groups at full-low frequency band, Slow-3 band, Slow-4 band, and Slow-5 band. After the acupuncture treatments, the patients with PDM in the verum acupuncture group showed significantly decreased VAS scores (p < 0.05). The frequency-dependent gFCD alternations were found in the verum acupuncture group, altered regions including DLPFC, somatosensory cortex, anterior cingulate cortex (ACC), middle cingulate cortex (MCC), precuneus, hippocampus, and insula. The sham acupuncture modulated regions including angular gyrus, inferior frontal gyrus, and hippocampus. The gFCD alternation in DLPFC at the Slow-5 band was negatively in the patients with PDM following verum acupuncture, and S2 at the Slow-4 band was positively correlated with VAS scores. These findings supported that verum acupuncture could effectively modulate frequency-dependent gFCD in PDM by influencing abnormal DLPFC at Slow-5 band and hippocampus at the Slow-3 band. The outcome of this study may shed light on enhancing the potency of acupuncture in clinical practice.
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影响因子：
5.7
作者：
Harris, Richard E.;Zubieta, Jon-Kar;Scott, David J.;Napadow, Vitaly;Gracely, Richard H.;Clauw, Daniel J.
通讯作者：
Clauw, Daniel J.
影响因子：
4.6
作者：
Jung WM;Lee IS;Wallraven C;Ryu YH;Park HJ;Chae Y
通讯作者：
Chae Y
影响因子：
3.7
作者：
Bajaj S;Adhikari BM;Dhamala M
通讯作者：
Dhamala M
DOI：
10.1523/jneurosci.1984-11.2011
发表时间：
2011-09-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Baliki MN;Baria AT;Apkarian AV
通讯作者：
Apkarian AV
影响因子：
16.2
作者：
Eippert, Falk;Bingel, Ulrike;Buechel, Christian
通讯作者：
Buechel, Christian