Pressure-driven collective growth mechanism of planar cell colonies
Pressure-driven collective growth mechanism of planar cell colonies
复制标题
压力驱动的平面细胞集落集体生长机制
DOI：
10.1088/1361-6463/aace4c
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Fabry B
中科院分区：
文献类型：
--
作者：
Metzner C;Lange J;Krauss P;Wunderling N;Übelacker J;Martin F;Fabry B
细胞集落的生长取决于单个细胞的迁移和增殖。这通常用Fisher-Kolmogorov（FK）方程建模，该方程假设细胞彼此独立扩散，但当它们的密度达到临界极限时停止增殖。然而，当使用测量的细胞系特定参数时，我们发现FK方程大大低估了实验观察到的菌落半径随时间的增加。此外，与随机扩散的假设相反，真实的集落中的细胞以超扩散轨迹径向向外迁移。我们证明，这两个dicreedum可以通过假设密集的集落中的细胞是由排斥，压力等力分开。使用这个模型的增殖排斥粒子，我们发现，菌落生长表现出不同的动力学制度，这取决于压力相关的平衡细胞密度和增殖停滞的临界密度之间的比率。
The growth of cell colonies is determined by the migration and proliferation of the individual cells. This is often modeled with the Fisher–Kolmogorov (FK) equation, which assumes that cells diffuse independently from each other, but stop to proliferate when their density reaches a critial limit. However, when using measured, cell-line specific parameters, we find that the FK equation drastically underestimates the experimentally observed increase of colony radius with time. Moreover, cells in real colonies migrate radially outward with superdiffusive trajectories, in contrast to the assumption of random diffusion. We demonstrate that both dicrepancies can be resolved by assuming that cells in dense colonies are driven apart by repulsive, pressure-like forces. Using this model of proliferating repelling particles, we find that colony growth exhibits different dynamical regimes, depending on the ratio between a pressure-related equilibrium cell density and the critial density of proliferation arrest.
影响因子：
9.7
作者：
Lang NR;Skodzek K;Hurst S;Mainka A;Steinwachs J;Schneider J;Aifantis KE;Fabry B
通讯作者：
Fabry B
影响因子：
3.7
作者：
Lange, Janina R.;Fabry, Ben
通讯作者：
Fabry, Ben