Cell and tissue mechanics in cell migration.

Cell and tissue mechanics in cell migration.
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DOI:
10.1016/j.yexcr.2013.04.023
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发表时间:
2013-10-01
影响因子:
3.7
通讯作者:
Fabry, Ben
Fabry, Ben
中科院分区:
医学3区
文献类型:
--
作者:
Lange, Janina R.;Fabry, Ben

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迁移的细胞产生牵引力来抵消细胞内应力和基质粘连所产生的运动阻力。在细胞群中的集体迁移,或通过结缔组织的三维迁移的情况下,运动阻力也来自外部应力。虽然更硬的细胞或基质的变形会引起更大的运动阻力,但同时,更大的刚度也可以促进细胞迁移,这是由于细胞的肌动蛋白收缩机制介导的力、变形和变形速度之间的反馈。这种机械反馈对于刚度感知、硬致性、硬致性和细胞群的集体迁移也很重要。
Migrating cells generate traction forces to counteract the movement-resisting forces arising from cell-internal stresses and matrix adhesions. In the case of collective migration in a cell colony, or in the case of 3-dimensional migration through connective tissue, movement-resisting forces arise also from external stresses. Although the deformation of a stiffer cell or matrix causes larger movement-resisting forces, at the same time a larger stiffness can also promote cell migration due to a feedback between forces, deformations, and deformation speed that is mediated by the acto-myosin contractile machinery of cells. This mechanical feedback is also important for stiffness sensing, durotaxis, plithotaxis, and collective migration in cell colonies.
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