One ring to rule them all: trafficking of heme and heme synthesis intermediates in the metazoans.
One ring to rule them all: trafficking of heme and heme synthesis intermediates in the metazoans.
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DOI：
10.1016/j.bbamcr.2012.04.009
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发表时间：
2012-09
影响因子：
5.1
通讯作者：
Dailey, Harry A.
中科院分区：
文献类型：
--
作者：
Hamza, Iqbal;Dailey, Harry A.
血红素（一种围绕铁原子的有机环）的出现，在进化过程中永远改变了生物体产生能量、利用气体和催化许多反应的效率。正因为如此，血红素已成为生物体中几乎无处不在的化合物。在这篇综述中，我们试图评估血红素合成和贩运的现状，目标是确定关键的缺失信息，并提出与贩运相关的假设，可能会产生讨论和研究。空间组织的超分子酶复合物和细胞器结构，促进有效的血红素合成和随后的贩运的可能性进行了讨论和评估。最近确定的球员血红素运输和贩运的审查和放置在一个有机体的背景下。此外，旧的，建立良好的数据重新审查，根据最近的研究细胞组织和数据，从较新的模式生物。
The appearance of heme, an organic ring surrounding an iron atom, in evolution forever changed the efficiency with which organisms were able to generate energy, utilize gasses and catalyze numerous reactions. Because of this, heme has become a near ubiquitous compound among living organisms. In this review we have attempted to assess the current state of heme synthesis and trafficking with a goal of identifying crucial missing information, and propose hypotheses related to trafficking that may generate discussion and research. The possibilities of spatially organized supramolecular enzyme complexes and organelle structures that facilitate efficient heme synthesis and subsequent trafficking are discussed and evaluated. Recently identified players in heme transport and trafficking are reviewed and placed in an organismal context. Additionally, older, well established data are reexamined in light of more recent studies on cellular organization and data available from newer model organisms.
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影响因子：
--
作者：
Chiabrando D;Tolosano E
通讯作者：
Tolosano E
影响因子：
4.8
作者：
Albakri, QA;Stuehr, DJ
通讯作者：
Stuehr, DJ
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11.4
作者：
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作者：
CLEMENS, LE;BASCH, PF
通讯作者：
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作者：
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通讯作者：
PONKA, P